ArticleScientific reports2022
The nano- and meso-scale structure of amorphous calcium carbonate.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 42 citations in OpenAlex.
- Composition-tunable polycarboxylic acid-stabilized ultrasmall amorphous paramagnetic nanoclusters as multifunctional MRI contrast agents.Materials today. Bio · 2026Article
- Navigating Classical and Nonclassical Realms of Nucleation and Crystallization.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- The glass transition of biologically secreted amorphous calcium carbonate.Materials advances · 2026Article
- In situ ptychographic x-ray nanotomography of temperature-controlled crystallization processes.Nature communications · 2026Article
- Ligand-Free MgCOACS applied materials & interfaces · 2026Article
- Chronic Wound Healing: Breakthrough Strategies Based on Inorganic Polyphosphate.Progress in molecular and subcellular biology · 2026Review
- Formation, chemical evolution and solidification of the dense liquid phase of calcium (bi)carbonate.Nature materials · 2025Article
- From Ions to Crystals: A Comprehensive View of the Non-Classical Nucleation of Calcium Sulfate.Angewandte Chemie (International ed. in English) · 2024Article
- Unlocking the potential of amorphous calcium carbonate: A star ascending in the realm of biomedical application.Acta pharmaceutica Sinica. B · 2024Review
- Effect of water on the glass transition of a potassium-magnesium carbonate melt.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023Article
- Glass transition temperatures and crystallization kinetics of a synthetic, anhydrous, amorphous calcium-magnesium carbonate.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2023Article
- Growth dynamics and amorphous-to-crystalline phase transformation in natural nacre.Nature communications · 2023Article
- Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate.Pharmaceutics · 2023Article
- The Kinetics of Aragonite Formation from Solution via Amorphous Calcium Carbonate.Nanomaterials (Basel, Switzerland) · 2022Article
- Structure of an amorphous calcium carbonate phase involved in the formation ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Small-Molecular-Weight Additives Modulate Calcification by Interacting with Prenucleation Clusters on the Molecular Level.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
15 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the underlying processes of biomineralization is crucial to a range of disciplines allowing us to quantify the effects of climate change on marine organisms, decipher the details of paleoclimate records and advance the development of biomimetic materials. Many biological minerals form via intermediate amorphous phases, which are hard to characterize due to their transient nature and a lack of long-range order. Here, using Monte Carlo simulations constrained by X-ray and neutron scattering data together with model building, we demonstrate a method for determining the structure of these intermediates with a study of amorphous calcium carbonate (ACC) which is a precursor in the bio-formation of crystalline calcium carbonates. We find that ACC consists of highly ordered anhydrous nano-domains of approx. 2 nm that can be described as nanocrystalline. These nano-domains are held together by an interstitial net-like matrix of water molecules which generate, on the mesoscale, a heterogeneous and gel-like structure of ACC. We probed the structural stability and dynamics of our model on the nanosecond timescale by molecular dynamics simulations. These simulations revealed a gel-like and glassy nature of ACC due to the water molecules and carbonate ions in the interstitial matrix featuring pronounced orientational and translational flexibility. This allows for viscous mobility with diffusion constants four to five orders of magnitude lower than those observed in solutions. Small and ultra-small angle neutron scattering indicates a hierarchically-ordered organization of ACC across length scales that allow us, based on our nano-domain model, to build a comprehensive picture of ACC formation by cluster assembly from solution. This contribution provides a new atomic-scale understanding of ACC and provides a framework for the general exploration of biomineralization and biomimetic processes.
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