Evidence map›Paper›PMID 35477683›Full record

Trial reportJournal of psychiatry & neuroscience : JPN

Frontoparietal paired associative stimulation versus single-site stimulation for generalized anxiety disorder: a pilot rTMS study.

Li Wang, Qi-Hui Zhou, Kun Wang, Hui-Cong Wang, Shi-Min Hu, Ying-Xue Yang, Yi-Cong Lin, Yu-Ping Wang

Erratum issuedOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Li WangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang) wangyuping01@sina.cn linyc_1@163.com.
Qi-Hui ZhouFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Kun WangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Hui-Cong WangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Shi-Min HuFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Ying-Xue YangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Yi-Cong LinFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang) wangyuping01@sina.cn linyc_1@163.com.
Yu-Ping WangFrom the Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Beijing Key Laboratory of Neuromodulation, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Centre of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Institute of Sleep and Consciousness Disorders, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China (L. Wang, Zhou, H. Wang, Hu, Yang, Lin, Y. Wang); the Department of Neurology, Beijing Puren Hospital, Beijing, China (K. Wang).
Beijing Tongren Hospital · CNInternational Neuromodulation Society · USCapital Medical University · CNChinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt present, the use of repetitive transcranial magnetic stimulation (rTMS) for generalized anxiety disorder (GAD) is limited to single-site interventions. We investigated whether dual-site frontoparietal stimulation delivered using cortical-cortical paired associative stimulation (ccPAS) had stronger clinical efficacy than single-site stimulation in patients with GAD.

methodsWe randomized 50 patients with GAD to 1 Hz rTMS (10 sessions) using 1 of the following protocols: single-site stimulation over the right dorsolateral prefrontal cortex (dlPFC; 1500 pulses per session); single-site stimulation over the right posterior parietal cortex (PPC; 1500 pulses per session); repetitive dual-site ccPAS (rds-ccPAS) over the right dlPFC and right PPC with 1500 pulses per session (rd-ccPAS-1500); or rds-ccPAS over the right dlPFC and right PPC with 750 pulses per session (rd-ccPAS-750). Both rds-ccPAS treatments used a between-site interval of 100 ms.

resultsClinical scores for anxiety, depression and insomnia were reduced in all 4 groups after treatment. We found greater improvements in anxiety symptoms in the rds-ccPAS-1500 group compared to the rds-ccPAS-750 and single-site groups. We found greater improvements in depression symptoms and insomnia in the rds-PAS-1500 group compared to the single-site groups. The rds-ccPAS-1500 group also showed significant or trend-level improvements in anxiety symptoms and insomnia at 10-day and 1-month followup. More patients responded to treatment with rds-ccPAS-1500 than with single-site stimulation. The between-group differences in response rates persisted to the 3-month follow-up. Treatment using rds-ccPAS with a between-site interval of 100 ms induced a more significant improvement than the between-site interval of 50 ms we evaluated in a previous study. LIMITATIONS: These results need to be replicated in a larger sample using sham control and equal-pulse single-site stimulation.

conclusionFrontoparietal rds-ccPAS may be a better treatment option for GAD.

Indexed as

Anxiety DisordersTranscranial Magnetic StimulationHumansParietal LobePilot ProjectsSleep Initiation and Maintenance DisordersTreatment Outcome

Identifiers

PMID35477683
PMCPMC9259432
OpenAlexW4225102754

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.