ArticleBMC women's health2022
Relationship between bone mineral density and ovarian function and thyroid function in perimenopausal women with endometriosis: a prospective study.
Article in BMC women's health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Routine Dysmenorrhea Screening in Adolescents: Recommendations for Timely Diagnosis and Treatment of Endometriosis.Journal of pediatrics. Clinical practice · 2026Article
- Review
- The iron-ferroptosis axis in bone homeostasis: a potential complementary pathway for osteoporosis in endometriosis.European journal of medical research · 2026Review
- Associations of AMH in Midreproductive Years with Bone Mineral Density and Turnover Markers in Midlife.The Journal of clinical endocrinology and metabolism · 2025Article
- Study on gut microbiota and metabolomics in postmenopausal women.BMC women's health · 2024Article
- Genetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study.Calcified tissue international · 2024Article
- Histone lactylation promotes cell proliferation, migration and invasion through targeting HMGB1 in endometriosis.Journal of biomedical research · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundIn women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the association between changes in bone mineral density (BMD) and clinical data, such as ovarian reserves, in perimenopausal women with endometriosis.
methodsIn this prospective study, we evaluated 207 female patients who visited the Department of Obstetrics and Gynecology at the University of Tokyo Hospital between December 2015 and December 2020. We included patients aged ≥ 40 years with a history of endometriosis or who presented with endometriosis lesions. Patients with a history of smoking, steroid administration, autoimmune diseases, dyslipidaemia, and heart disease were excluded. During the study period, patients who underwent two tests, an initial and a follow-up test (n = 142, average age: 45.02 years, average BMD: 1.16 g/cm
resultsThere was a weak negative correlation between the follicle-stimulating hormone (FSH) and BMD and a weak positive correlation between the anti-Müllerian hormone (AMH) and BMD. The annual rate of change in BMD showed a very weak correlation with thyroid-stimulating hormone (TSH) levels. A large decline in BMD was associated with high TSH levels and higher average age at menopause. Patients with higher TSH exhibited a higher rate of decrease in BMD than those without.
conclusionsHigh FSH or low AMH levels are associated with decreased BMD. Decreased ovarian reserve is associated with decreased BMD in perimenopausal women with endometriosis. High TSH levels increase the risk of BMD loss. This finding may suggest that women with endometriosis should undergo bone scanning to rule out the possibility of reduced bone mass and subsequent increased risk of fracture.
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