Evidence map›Paper›PMID 35477478›Full record

ArticleCell & bioscience2022

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA

Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L Whittsette, Joseph W Lynch, R Luke Wiseman, Jeffery W Kelly, Angelo Keramidas, Ting-Wei Mu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. GABASynapse (New York, N.Y.) · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  8. Review
  9. bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Pathogenicity Prediction of GABAbioRxiv : the preprint server for biology · 2023
    Article
  16. Ceapin-A7 potentiates lipopolysaccharide-induced endothelial injury.Journal of biochemical and molecular toxicology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Meng Wang *Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Edmund Cotter *Queensland Brain Institute, the University of Queensland, Brisbane, QLD, 4072, Australia.
Ya-Juan WangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Xu FuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Angela L WhittsetteDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Joseph W LynchQueensland Brain Institute, the University of Queensland, Brisbane, QLD, 4072, Australia.
R Luke WisemanDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Jeffery W KellyDepartment of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Angelo KeramidasQueensland Brain Institute, the University of Queensland, Brisbane, QLD, 4072, Australia. a.keramidas@uq.edu.au.
Ting-Wei MuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA. tingwei.mu@case.edu.ORCID http://orcid.org/0000-0002-6419-9296
University School · USThe University of Queensland · AUScripps Research Institute · US

Funding

Discovering small molecules activators of stress responsive signalingR01AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI JEFFERY W KELLY, Rockland Luke Wiseman · 2013 to 2026
$6.0M
Understanding GABAA receptor protein folding and misfoldingR01NS105789 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Tingwei Mu · 2018 to 2026
$3.9M
Discovering Small Molecule Activators of Stress-Responsive SignalingRF1AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W, WISEMAN, ROCKLAND LUKE · 2023 to 2025
$2.8M
Assembly Chaperone Complex for Membrane Proteins in the Endoplasmic ReticulumR01NS117176 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MU, TINGWEI · 2020 to 2023
$1.6M
NIA NIH HHS R01 AG046495NIA NIH HHS R01AG046495NIA NIH HHS RF1 AG046495NINDS NIH HHS R01 NS105789NINDS NIH HHS R01NS105789NINDS NIH HHS R01 NS117176NINDS NIH HHS R01NS117176
6 · The paper itself

Abstract

backgroundGenetic variants in the subunits of the gamma-aminobutyric acid type A (GABA

resultsHere, we demonstrate that pharmacologically enhancing endoplasmic reticulum (ER) proteostasis using small molecule activators of the ATF6 (Activating Transcription Factor 6) signaling arm of the unfolded protein response (UPR) increases the assembly, trafficking, and surface expression of variant GABA

conclusionsThese results indicate that pharmacologic ATF6 activators offer an opportunity to restore GABA

Identifiers

PMID35477478
PMCPMC9044816
OpenAlexW4224935505

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.