ArticleBMC biology2022
Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development.
Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
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- A Review of the Literature on the Endocrine Disruptor Activity Testing of Bisphenols inJournal of xenobiotics · 2026Review
- TheToxicology reports · 2025Article
- Insulin and epidermal signals independently shape sexually dimorphic neurite branching in C. elegans.EMBO reports · 2025Article
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- The egg-counter: a novel microfluidic platform for characterization ofLab on a chip · 2024Article
- The effect of developmental variation on expression QTLs in a multi parental Caenorhabditis elegans population.G3 (Bethesda, Md.) · 2024Article
- Uncovering developmental time and tempo using deep learning.Nature methods · 2023Article
- Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies inACS omega · 2023Review
- Reply to Zhang et al.: The critical temperature dependence of developmental rates is in search of a mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans.Nature communications · 2022Article
- Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development.BMC biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAfter embryonic development, Caenorhabditis elegans progress through for larval stages, each of them finishing with molting. The repetitive nature of C. elegans postembryonic development is considered an oscillatory process, a concept that has gained traction from regulation by a circadian clock gene homologue. Nevertheless, each larval stage has a defined duration and entails specific events. Since the overall duration of development is controlled by numerous factors, we have asked whether different rate-limiting interventions impact all stages equally.
resultsWe have measured the duration of each stage of development for over 2500 larvae, under varied environmental conditions known to alter overall developmental rate. We applied changes in temperature and in the quantity and quality of nutrition and analysed the effect of genetically reduced insulin signalling. Our results show that the distinct developmental stages respond differently to these perturbations. The changes in the duration of specific larval stages seem to depend on stage-specific events. Furthermore, our high-resolution measurement of the effect of temperature on the stage-specific duration of development has unveiled novel features of temperature dependence in C. elegans postembryonic development.
conclusionsAltogether, our results show that multiple factors fine tune developmental timing, impacting larval stages independently. Further understanding of the regulation of this process will allow modelling the mechanisms that control developmental timing.
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