ArticleCell reports2022
An increase in spontaneous activity mediates visual habituation.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Visual Threat Location Impacts Brain-Wide Visual Adaptation Networks.The Journal of comparative neurology · 2026Article
- Eye Opening Primes Synaptic Maturation by Enhancing AMPA Receptor-Mediated Transmission and Spinogenesis in the Developing Superior Colliculus.Molecular neurobiology · 2025Article
- Neural signature of chronic migraine mice model and related photophobia in the primary visual cortex.The journal of headache and pain · 2025Article
- HIV-1 Tat protein alters medial prefrontal cortex neuronal activity and recognition memory.iScience · 2025Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity.Scientific reports · 2023Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions.Cell reports · 2023Article
- Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex with chronic two-photon calcium imaging during visual habituation to a specific oriented stimulus. We find that, during habituation, spontaneous activity increases in neurons across the full range of orientation selectivity, eventually matching that of evoked levels. This increase in spontaneous activity robustly correlates with the degree of habituation. Moreover, boosting spontaneous activity with two-photon optogenetic stimulation to the levels of visually evoked activity accelerates habituation. Our study shows that cortical spontaneous activity is linked to habituation, and we propose that habituation unfolds by minimizing the difference between spontaneous and stimulus-evoked activity levels. We conclude that baseline spontaneous activity could gate incoming sensory information to the cortex based on the learned experience of the animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.