Evidence map›Paper›PMID 35476918›Full record

ArticleACS chemical biology2022

Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic Pathogen

Lukuan Hou, Hai-Yan Tian, Li Wang, Zachary E Ferris, Junfeng Wang, Mingwei Cai, Ethan A Older, Manikanda Raja Keerthi Raja, Dan Xue, Wanyang Sun and 6 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Lukuan HouDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Hai-Yan TianCollege of Pharmacy, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-2421-8712
Li WangCollege of Pharmacy, Jinan University, Guangzhou 510632, China.
Zachary E FerrisDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Junfeng WangDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, United States.
Mingwei CaiInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China.
Ethan A OlderDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Manikanda Raja Keerthi RajaDepartment of Biological Sciences, University of South Carolina, Columbia, South Carolina 29209, United States.
Dan XueDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Wanyang SunCollege of Pharmacy, Jinan University, Guangzhou 510632, China.
Prakash NagarkattiDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, United States.
Mitzi NagarkattiDepartment of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, United States.
Hexin ChenDepartment of Biological Sciences, University of South Carolina, Columbia, South Carolina 29209, United States.
Daping FanDepartment of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina 29209, United States.
Xiaoyu TangInstitute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China.ORCID 0000-0002-7855-5984
Jie LiDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0001-7977-6749
University of South Carolina · USJinan University · CNShenzhen Bay Laboratory · CN

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI KIARIS, HIPPOKRATIS, RONINSON, IGOR B · 2014 to 2024
$25.2M
Targeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY, NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7M
NIGMS NIH HHS P20 GM103641NIGMS NIH HHS P20 GM109091
6 · The paper itself

Abstract

Sulfonolipids (SoLs) are a unique class of sphingolipids featuring a sulfonate group compared to other sphingolipids. However, the biological functions and biosynthesis of SoLs in human microbiota have been poorly understood. Here, we report the discovery and isolation of SoLs from a human opportunistic pathogen

Indexed as

Cysteic AcidSphingolipidsAcyltransferasesAnimalsChryseobacteriumLipidsMiceAcyltransferasesCysteic AcidLipidsSphingolipidssulfolipids

Identifiers

PMID35476918
PMCPMC9275813
OpenAlexW4224979693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.