Evidence map›Paper›PMID 35476655›Full record

ArticleThe New England journal of medicine2022

CTLA-4 Blockade Resistance after Relatlimab and Nivolumab.

Alexander M Menzies, Ines Pires da Silva, Claudia Trojaniello, Elisabeth Vieu, Rodabe N Amaria, Lisa Zimmer, Serigne N Lo, Elizabeth M Burton, Hussein A Tawbi, Dirk Schadendorf and 3 more

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. The Challenge of Treating Anti-PD-1-Resistant Advanced Melanoma.American journal of clinical dermatology · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Overcoming Resistance Mechanisms to Melanoma Immunotherapy.American journal of clinical dermatology · 2025
    Review
  9. Article
  10. Review
  11. Pilot Study of ONCOS-102 and Pembrolizumab: Remodeling of the Tumor Microenvironment and Clinical Outcomes in Anti-PD-1-Resistant Advanced Melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Alexander M MenziesMelanoma Institute Australia, Sydney, NSW, Australia.
Ines Pires da SilvaMelanoma Institute Australia, Sydney, NSW, Australia.
Claudia TrojanielloIstituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.
Elisabeth VieuAssistance Publique-Hôpitaux de Marseille Timone, Marseille, France.
Rodabe N AmariaUniversity of Texas M.D. Anderson Cancer Center, Houston, TX.
Lisa ZimmerUniversity Hospital Essen, Essen, Germany.
Serigne N LoMelanoma Institute Australia, Sydney, NSW, Australia.
Elizabeth M BurtonUniversity of Texas M.D. Anderson Cancer Center, Houston, TX.
Hussein A TawbiUniversity of Texas M.D. Anderson Cancer Center, Houston, TX.ORCID 0000-0003-1942-851X
Dirk SchadendorfUniversity Hospital Essen, Essen, Germany.ORCID 0000-0003-3524-7858
Jean J GrobAssistance Publique-Hôpitaux de Marseille Timone, Marseille, France.
Paolo A AsciertoIstituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Italy.ORCID 0000-0002-8322-475X
Georgina V LongMelanoma Institute Australia, Sydney, NSW, Australia.ORCID 0000-0001-8894-3545

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibodies, Monoclonal, HumanizedCTLA-4 AntigenDrug ResistanceNivolumabAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalDrug Resistance, NeoplasmHumansImmune Checkpoint InhibitorsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalCTLA-4 AntigenCTLA4 protein, humanImmune Checkpoint InhibitorsNivolumabrelatlimab

Identifiers

PMID35476655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.