Evidence map›Paper›PMID 35476648›Full record

ArticleBlood2022

Subclonal evolution of CLL driver mutations is associated with relapse in ibrutinib- and acalabrutinib-treated patients.

Gage S Black, Xiaomeng Huang, Yi Qiao, Szabolcs Tarapcsak, Kerry A Rogers, Shrilekha Misra, John C Byrd, Gabor T Marth, Deborah M Stephens, Jennifer A Woyach

Open access · greenAbstract read
In one paragraph

Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Novel therapies and combinations in CLL refractory to BTK inhibitors and venetoclax.Hematology. American Society of Hematology. Education Program · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gage S BlackDepartment of Human Genetics, University of Utah, Salt Lake City, UT;ORCID 0000-0003-2086-5266
Xiaomeng HuangDepartment of Human Genetics, University of Utah, Salt Lake City, UT;
Yi QiaoDepartment of Human Genetics, University of Utah, Salt Lake City, UT;
Szabolcs TarapcsakDepartment of Human Genetics, University of Utah, Salt Lake City, UT;ORCID 0000-0001-7182-0135
Kerry A RogersDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.ORCID 0000-0001-5748-7874
Shrilekha MisraDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
John C ByrdDepartment of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH; and.
Gabor T MarthDepartment of Human Genetics, University of Utah, Salt Lake City, UT;
Deborah M StephensDivision of Hematology and Hematologic Malignancies, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.ORCID 0000-0001-9188-5008
Jennifer A WoyachDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH.
University of Utah · USThe Ohio State University · USUniversity of Cincinnati Medical Center · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Targeted Therapy for Lymphoid MalignanciesR01CA177292 · NCI · OHIO STATE UNIVERSITY · PI ROGERS, KERRY ANNE, WOYACH, JENNIFER A. · 2013 to 2025
$5.3M
Monitoring tumor subclonal heterogeneity over time and spaceU24CA209999 · NCI · UNIVERSITY OF UTAH · PI MARTH, GABOR T, QUINLAN, AARON R · 2016 to 2020
$3.9M
IOBIO: Web-based, interactive tools for real-time analysis in genomic big dataR01HG009000 · NHGRI · UNIVERSITY OF UTAH · PI MARTH, GABOR T · 2017 to 2020
$2.9M
Improving BTK Directed Therapy for CLLR01CA197870 · NCI · OHIO STATE UNIVERSITY · PI WOYACH, JENNIFER A. · 2015 to 2019
$1.8M
Novel Strategies to Eliminate Resistance to B-cell Receptor Inhibitor Therapy in Lymphoid MalignanciesK23CA212271 · NCI · UNIVERSITY OF UTAH · PI STEPHENS, DEBORAH · 2016 to 2020
$902k
From genomics to natural language processing: A protected environment for research computing in the health scienceS10OD021644 · OD · UNIVERSITY OF UTAH · PI CHEATHAM, THOMAS E. · 2017 to 2017
$494k
NCI NIH HHS K23 CA212271NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA042014NCI NIH HHS R01 CA177292NCI NIH HHS R01 CA197870NCI NIH HHS U24 CA209999NHGRI NIH HHS R01 HG009000NIH HHS S10 OD021644
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellAdenineBenzamidesHumansMutationNeoplasm Recurrence, LocalPiperidinesProtein Kinase InhibitorsPyrazinesacalabrutinibAdenineBenzamidesibrutinibPiperidinesProtein Kinase InhibitorsPyrazines

Identifiers

PMID35476648
PMCPMC9335504
OpenAlexW4225091971

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.