Evidence map›Paper›PMID 35476640›Full record

ArticleeLife2022

The role of V3 neurons in speed-dependent interlimb coordination during locomotion in mice.

Han Zhang, Natalia A Shevtsova, Dylan Deska-Gauthier, Colin Mackay, Kimberly J Dougherty, Simon M Danner, Ying Zhang, Ilya A Rybak

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  11. Spinal cord morphology and PKD2L1Frontiers in neuroanatomy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Han Zhang *Department of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, Canada.ORCID 0000-0001-5494-3504
Natalia A Shevtsova *Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, United States.ORCID 0000-0002-1971-9707
Dylan Deska-GauthierDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Colin MackayDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, Canada.
Kimberly J DoughertyDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, United States.ORCID 0000-0002-0807-574X
Simon M Danner *Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, United States.ORCID 0000-0002-4642-7064
Ying Zhang *Department of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, Canada.ORCID 0000-0003-4363-5666
Ilya A Rybak *Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, United States.ORCID 0000-0003-3461-349X

Funding

Crucial spinal circuit changes that mediate locomotor benefits and deficits following combined therapies after spinal cord injuryR01NS104194 · NINDS · DREXEL UNIVERSITY · PI Kimberly J Dougherty, SIMON F GISZTER · 2018 to 2026
$4.2M
Limb coordination during locomotion before and after spinal cord injuryR01NS110550 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI BORIS I PRILUTSKY, Ilya A Rybak · 2020 to 2026
$3.9M
Propriopsinal neuron function in normal and post-SCI locomotionR01NS112304 · NINDS · UNIVERSITY OF LOUISVILLE · PI Simon Michael Danner, David SK Magnuson · 2021 to 2026
$3.0M
Neural mechanisms of locomotion evoked by epidural stimulation of the spinal cordR01NS100928 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI PRILUTSKY, BORIS I · 2017 to 2021
$2.7M
Spinal circuits for sensorimotor integration and interlimb coordination during locomotionR01NS115900 · NINDS · DREXEL UNIVERSITY · PI DANNER, SIMON MICHAEL · 2020 to 2024
$1.7M
Specific spinal locomotor circuit alterations induced by epidural stimulationR21NS118226 · NINDS · DREXEL UNIVERSITY · PI DOUGHERTY, KIMBERLY J · 2020 to 2020
$416k
NINDS NIH HHS R01 NS100928NINDS NIH HHS R01 NS104194NINDS NIH HHS R01 NS110550NINDS NIH HHS R01 NS112304NINDS NIH HHS R01 NS115900NINDS NIH HHS R21 NS118226
6 · The paper itself

Abstract

Speed-dependent interlimb coordination allows animals to maintain stable locomotion under different circumstances. The V3 neurons are known to be involved in interlimb coordination. We previously modeled the locomotor spinal circuitry controlling interlimb coordination (Danner et al., 2017). This model included the local V3 neurons that mediate mutual excitation between left and right rhythm generators (RGs). Here, our focus was on V3 neurons involved in ascending long propriospinal interactions (aLPNs). Using retrograde tracing, we revealed a subpopulation of lumbar V3 aLPNs with contralateral cervical projections. V3

Indexed as

LocomotionNeuronsAnimalsMiceWalkingcetral pattern generatorcommissural interneuronscomputational modelinglocomotionlong propriospinal neuronsmouseneurosciencespinal cord

Identifiers

PMID35476640
PMCPMC9045817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.