Evidence map›Paper›PMID 35476589›Full record

Observational studyJournal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

Eighteen-month Course and Outcome of Adolescent Restrictive Eating Disorders: Persistence, Crossover, and Recovery.

Lauren Breithaupt, Danielle L Kahn, Meghan Slattery, Franziska Plessow, Christopher Mancuso, Alyssa Izquierdo, Melissa J Dreier, Kendra Becker, Debra L Franko, Jennifer J Thomas and 4 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  14. Prospective 2-Year Course and Predictors of Outcome in Avoidant/Restrictive Food Intake Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2025
    Article
  15. Perceptual Dysfunction in Eating Disorders.Current topics in behavioral neurosciences · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Avoidant/Restrictive Food Intake Disorder: Review and Recent Advances.Focus (American Psychiatric Publishing) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lauren BreithauptEating Disorders Clinical and Research Program, Massachusetts General Hospital.ORCID 0000-0002-2439-6519
Danielle L KahnNeuroendocrine Unit, Massachusetts General Hospital.
Meghan SlatteryNeuroendocrine Unit, Massachusetts General Hospital.
Franziska PlessowDepartment of Psychiatry, Harvard Medical School.
Christopher MancusoNeuroendocrine Unit, Massachusetts General Hospital.
Alyssa IzquierdoNeuroendocrine Unit, Massachusetts General Hospital.
Melissa J DreierEating Disorders Clinical and Research Program, Massachusetts General Hospital.
Kendra BeckerEating Disorders Clinical and Research Program, Massachusetts General Hospital.
Debra L FrankoDepartment of Psychology, Northeastern University.
Jennifer J ThomasEating Disorders Clinical and Research Program, Massachusetts General Hospital.ORCID 0000-0003-2601-581X
Laura HolsenDepartment of Psychiatry, Harvard Medical School.ORCID 0000-0003-1292-7789
Elizabeth A LawsonDepartment of Psychiatry, Harvard Medical School.ORCID 0000-0001-8619-3349
Madhusmita MisraDepartment of Psychiatry, Harvard Medical School.
Kamryn T EddyEating Disorders Clinical and Research Program, Massachusetts General Hospital.ORCID 0000-0002-1586-0930

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Takara Leah Stanley · 1994 to 2026
$31.6M
Aging of Emotion Circuitry: Impact of Sex, Depression, and Fetal Immune OriginsR01AG057505 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JILL M GOLDSTEIN · 2018 to 2026
$8.5M
The Role of Estrogen in the Neurobiology of Eating Disorders: A Study of Cognitive Flexibility and Reward in Eating DisordersR01MH116205 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, MISRA, MADHUSMITA · 2019 to 2023
$4.7M
Homeostatic and Hedonic Food Motivation Underlying Eating Disorder TrajectoriesR01MH103402 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI EDDY, KAMRYN T, LAWSON, ELIZABETH AUSTEN · 2014 to 2018
$3.7M
Oxytocin as a Neuroendocrine Therapy for Obesity in YouthR01DK124223 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Miriam Antoinette Bredella, Elizabeth Austen Lawson · 2020 to 2026
$3.7M
Neurobiological and Behavioral Risk Mechanisms of Youth Avoidant/Restrictive Eating TrajectoriesR01MH108595 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN, MICALI, NADIA · 2016 to 2020
$3.4M
Bone Metabolism in Adolescents Undergoing Bariatric SurgeryR01DK103946 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE, MISRA, MADHUSMITA · 2015 to 2019
$3.2M
Sex, Hormones and GABA in Stress Induced Anhedonia in DepressionR01MH108602 · NIMH · MCLEAN HOSPITAL · PI GOLDSTEIN, JILL M, PIZZAGALLI, DIEGO A · 2016 to 2020
$3.2M
Oxytocin and Weight Loss in HumansR01DK109932 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LAWSON, ELIZABETH AUSTEN · 2017 to 2020
$2.7M
Determinants of bone microarchitectural compromise in youth with type 1 diabetesR01DK122581 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BOUXSEIN, MARY L, MISRA, MADHUSMITA · 2019 to 2023
$2.0M
Translational Neuroscience Training for CliniciansT32MH112485 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BUCKNER, RANDY L, ROFFMAN, JOSHUA LAWRENCE · 2018 to 2022
$1.7M
NCATS NIH HHS UL1 TR002541NIAMS NIH HHS R21 AR072351NIA NIH HHS R01 AG057505NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK103946NIDDK NIH HHS R01 DK109932NIDDK NIH HHS R01 DK122581NIDDK NIH HHS R01 DK124223NIMH NIH HHS K23 MH125143NIMH NIH HHS K23 MH127465NIMH NIH HHS K24 MH120568NIMH NIH HHS R01 MH103402NIMH NIH HHS R01 MH108595NIMH NIH HHS R01 MH108602NIMH NIH HHS R01 MH116205NIMH NIH HHS R03 MH126143NIMH NIH HHS T32 MH112485
6 · The paper itself

Abstract

objectiveIn adults, low-weight restrictive eating disorders, including anorexia nervosa (AN), are marked by chronicity and diagnostic crossover from restricting to binge-eating/purging. Less is known about the naturalistic course of these eating disorders in adolescents, particularly atypical AN (atyp-AN) and avoidant/restrictive food intake disorder (ARFID). To inform nosology of low-weight restrictive eating disorders in adolescents, we examined outcomes including persistence, crossover, and recovery in an 18-month observational study.

methodWe assessed 82 women (ages 10-23 years) with low-weight eating disorders including AN (

resultsAmong all diagnoses, the likelihood of remaining stable within a given diagnosis was greater than that of transitioning, with the greatest probability among ARFID (0.84) and AN-R (0.62). Persistence of BP and atypical presentations at follow-up periods was less stable (AN-BP probability 0.40; atyp-AN-R probability 0.48; atyp-AN-BP probability, 0.50). Crossover from binge-eating/purging to restricting occurred 72% of the time; crossover from restricting to binge-eating/purging occurred 23% of the time. The likelihood of stable recovery (e.g., recovery at both 9 M and 18 M) was between 0.00 and 0.36.

conclusionAcross groups, intake diagnosis persisted in about two-thirds, and recovery was infrequent, underscoring the urgent need for innovative treatment approaches to these illnesses. Frequent crossover between AN and atyp-AN supports continuity between typical and atypical presentations, whereas no crossover to ARFID supports its distinction.

Indexed as

Anorexia NervosaBinge-Eating DisorderBulimiaFeeding and Eating DisordersAdolescentAdultChildFemaleHumansRetrospective StudiesYoung Adult

Identifiers

PMID35476589
PMCPMC9444807

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.