ArticleProceedings of the National Academy of Sciences of the United States of America2022
Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Microengineered Gradient Hydrogels for Mechanobiology.Advanced healthcare materials · 2026Review
- The Interplay Between Stiffness and Hyperglycemia on Diabetic Foot Ulcer Wound Closure.Cellular and molecular bioengineering · 2026Article
- Hyperplastic growth, not hydrostatic distension, in endolymphatic hydrops in humans challenges the classic view of Meniere's disease.Scientific reports · 2025Article
- Galvanotactic directionality of cell groups depends on group size.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stress fiber contraction induces cell body rotation in single keratocytes.Biophysics and physicobiology · 2025Article
- A low-cost electric micromanipulator and its application to single-cell electroporation.Biophysics and physicobiology · 2025Article
- Tumour follower cells: A novel driver of leader cells in collective invasion (Review).International journal of oncology · 2023Review
- Who's really in charge: Diverse follower cell behaviors in collective cell migration.Current opinion in cell biology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective cell migration is seen in many developmental and pathological processes, such as morphogenesis, wound closure, and cancer metastasis. When a fish scale is detached and adhered to a substrate, epithelial keratocyte sheets crawl out from it, building a semicircular pattern. All the keratocytes at the leading edge of the sheet have a single lamellipodium, and are interconnected with each other via actomyosin cables. The leading edge of the sheet becomes gradually longer as it crawls out from the scale, regardless of the cell-to-cell connections. In this study, we found leading-edge elongation to be realized by the interruption of follower cells into the leading edge. The follower cell and the two adjacent leader cells are first connected by newly emerging actomyosin cables. Then, the contractile forces along the cables bring the follower cell forward to make it a leader cell. Finally, the original cables between the two leader cells are stretched to tear by the interruption and the lamellipodium extension from the new leader cell. This unique actomyosin-cable reconnection between a follower cell and adjacent leaders offers insights into the mechanisms of collective cell migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.