ArticleJournal of the American Chemical Society2022
Ir-Catalyzed Asymmetric Allylic Alkylation of Dialkyl Malonates Enabling the Construction of Enantioenriched All-Carbon Quaternary Centers.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Stereoselective Prenylation of Aryl- and Heteroaryl Halides: γ-Selective Suzuki-Miyaura Coupling as a Tool for Asymmetric CspThe Journal of organic chemistry · 2026Article
- Stereodivergent Access to Aliphatic Nitro Compounds Bearing Multi-Contiguous Stereocenters via Sequential Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mo-Catalyzed Asymmetric Allylic Alkylation Enabling the Construction of Highly Enantioenriched 1,4-Dicarbonyl Scaffolds.Journal of the American Chemical Society · 2025Article
- Formation of Vicinal Secondary and All-Carbon Quaternary Stereocenters in Enantioenriched Diazenes via Branched-Selective Pd-Catalyzed Allylic Alkylation.Tetrahedron letters · 2025Article
- Experimental and Computational Studies on Cobalt(I)-Catalyzed Regioselective Allylic Alkylation Reactions.Angewandte Chemie (International ed. in English) · 2023Article
- Scope and Mechanistic Probe into Asymmetric Synthesis of α-Trisubstituted-α-Tertiary Amines by Rhodium Catalysis.Journal of the American Chemical Society · 2023Article
- Hydroxy-directed iridium-catalyzed enantioselective formal β-C(spChemical science · 2022Article
- Borylated Cyclopropanes as Spring-Loaded Entities: Access to Vicinal Tertiary and Quaternary Carbon Stereocenters in Acyclic Systems.Journal of the American Chemical Society · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
An enantioselective iridium-catalyzed allylic alkylation of malonates with trisubstituted allylic electrophiles to form all-carbon quaternary stereocenters is reported. This reaction proceeds at ambient temperature and enables the preparation of a wide range of enantioenriched products in up to 93% yield and 97% ee. The quaternary products can be readily converted to several valuable building blocks such as vicinal quaternary products and β-quaternary acids.
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Registered trials
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