Evidence map›Paper›PMID 35476447›Full record

ArticleScience advances2022

Mechanical tension mobilizes Lgr6

Yingchao Xue, Chenyi Lyu, Ainsley Taylor, Amy Van Ee, Ashley Kiemen, YoungGeun Choi, Nima Khavanian, Dominic Henn, Chaewon Lee, Lisa Hwang and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Lgr6Genes & diseases · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 2 countries.

Yingchao XueDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-7830-3146
Chenyi LyuDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0003-3570-3702
Ainsley TaylorDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21231, USA.
Amy Van EeDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-1277-3137
Ashley KiemenDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-6281-2616
YoungGeun ChoiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0003-3494-9145
Nima KhavanianDepartment of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD 21231, USA.
Dominic HennDepartment of Plastic Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Chaewon LeeDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-0277-8559
Lisa HwangDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-8951-8487
Eric WierDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0003-3824-410X
Saifeng WangDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.
Sam LeeDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0003-3760-8960
Ang LiDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-3421-5726
Charles KirbyDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-7756-2114
Gaofeng WangDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.
Pei-Hsun WuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-7371-2960
Denis WirtzDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-6147-3045
Luis A GarzaDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0002-6547-9695
Sashank K ReddyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.ORCID 0000-0001-6323-3950
Johns Hopkins University · USSouthwestern Medical Center · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Retinoic acid synthesis induced by noncoding dsRNA controls RegenerationR01AR074846 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2019 to 2023
$2.3M
Mechanism and clinical pilot tst of volar fibroblast to create ectopic volar skinR01AR064297 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2013 to 2017
$1.8M
Future Academic Scientists in DermatologyT32AR074920 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Luis Andres Garza · 2020 to 2026
$1.4M
Towards the clinical testing of dsRNA to promote wound induced hair neogenesisR01AR068280 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2016 to 2018
$718k
Injection of autologous volar fibroblasts to the stump site to allow pressure adaptation and enhanced prosthetic use in amputeesUG3AR079376 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI GARZA, LUIS ANDRES · 2021 to 2021
$532k
Endogenous RNA sensing as a stimulant of skin regenerationF32AR074865 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI WIER, ERIC MATTHEW · 2019 to 2020
$127k
NIAMS NIH HHS F32 AR074865NIAMS NIH HHS R01 AR064297NIAMS NIH HHS R01 AR068280NIAMS NIH HHS R01 AR074846NIAMS NIH HHS T32 AR074920NIAMS NIH HHS UG3 AR079376NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Uniquely among mammalian organs, skin is capable of marked size change in adults, yet the mechanisms underlying this notable capacity are unclear. Here, we use a system of controlled tissue expansion in mice to uncover cellular and molecular determinants of skin growth. Through machine learning-guided three-dimensional tissue reconstruction, we capture morphometric changes in growing skin. We find that most growth is driven by the proliferation of the epidermis in response to mechanical tension, with more limited changes in dermal and subdermal compartments. Epidermal growth is achieved through preferential activation and differentiation of Lgr6

Indexed as

Epidermal CellsReceptors, G-Protein-CoupledSkinStem CellsAnimalsEpidermisMiceLgr6 protein, mouseReceptors, G-Protein-Coupled

Identifiers

PMID35476447
PMCPMC9045722
OpenAlexW4224925099

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.