Evidence map›Paper›PMID 35476440›Full record

ArticleScience advances2022

Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival.

Pei-Yuan Bai, Si-Qin Chen, Dai-Le Jia, Li-Hong Pan, Chao-Bao Liu, Jin Liu, Wei Luo, Yang Yang, Ma-Yu Sun, Nai-Fu Wan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. Upregulation ofGut microbes · 2025
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  7. Gut microbiota and atrial cardiomyopathy.Frontiers in cardiovascular medicine · 2025
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  8. Review
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  10. IKKα-STAT3-S727 axis: a novel mechanism in DOX-induced cardiomyopathy.Cellular and molecular life sciences : CMLS · 2024
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Sulfated oligosaccharide activates endothelial Notch for inducing macrophage-associated arteriogenesis to treat ischemic diseases.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Use of Personal Resources May Influence the Rate of Biological Aging Depending on Individual Typology.European journal of investigation in health, psychology and education · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Pei-Yuan BaiDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.ORCID 0000-0001-7812-2495
Si-Qin ChenKey Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China.ORCID 0000-0003-3449-702X
Dai-Le JiaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.ORCID 0000-0002-9497-1574
Li-Hong PanKey Laboratory of Viral Heart Diseases, National Health Commission, Shanghai, China.ORCID 0000-0002-1995-2373
Chao-Bao LiuSchool of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-3049-713X
Jin LiuDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.
Wei LuoDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.ORCID 0000-0001-9416-9592
Yang YangState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-8714-9729
Ma-Yu SunState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Nai-Fu WanDepartment of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Wu-Wei RongDepartment of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ai-Jun SunDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.ORCID 0000-0003-1488-0937
Jun-Bo GeDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNRuijin Hospital · CNShanghai Jiao Tong University · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play a vital role in cardiac repair following myocardial infarction (MI). An enriched environment (EE) is involved in the regulation of macrophage-related activities and disease progression; however, whether EE affects the phenotype and function of macrophages to improve postinfarction cardiac repair remains unknown. In this study, we found that EE improved cardiac function, decreased mortality, and ameliorated adverse ventricular remodeling in mice after MI, with these outcomes closely related to the increased survival of Ly6C

Indexed as

Myocardial InfarctionVentricular RemodelingAnimalsBrain-Derived Neurotrophic FactorHeartMacrophagesMiceMyocardiumBrain-Derived Neurotrophic Factor

Identifiers

PMID35476440
PMCPMC9045726
OpenAlexW4224930212

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.