ArticleScience advances2022
A unified 3D map of microscopic architecture and MRI of the human brain.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Improved Post-Processing Framework for Whole Slide Imaging and 3D Reconstruction.Microscopy research and technique · 2026Article
- A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology.Scientific data · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- A unified 3D reconstruction of microscopy and MRI in a brain showing Alzheimer's disease-related neuropathology.Brain pathology (Zurich, Switzerland) · 2026Article
- Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI.Communications biology · 2026Article
- Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microstructural profiles of the human superficial white matter and their associations to cortical geometry and connectivity.PLoS biology · 2026Article
- Mapping the human thalamus: a historical review of thalamic atlases from histology to modern neuroanatomy.Frontiers in neuroanatomy · 2026Review
- Article
- HippoMaps: multiscale cartography of human hippocampal organization.Nature methods · 2025Article
- Brainbuilder: a software pipeline for 3D reconstruction of cortical maps from multi-modal 2D data sets.Communications biology · 2025Article
- Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface Imaging.bioRxiv : the preprint server for biology · 2025Article
- Article
- Rudolf Nieuwenhuys's later studies in neuroanatomy and functional neuroimaging.Brain structure & function · 2025Article
- In the brain of the beholder: bi-stable motion reveals mesoscopic-scale feedback modulation in V1.Brain structure & function · 2025Article
- Precise MRI-histology coregistration of paraffin-embedded tissue with blockface imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Automated parcellation and atlasing of the human subcortex with ultra-high resolution quantitative MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- A roadmap towards standardized neuroimaging approaches for human thalamic nuclei.Nature reviews. Neuroscience · 2024Review
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Gradients of Brain Organization: Smooth Sailing from Methods Development to User Community.Neuroinformatics · 2024Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.
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