Trial reportEuropean journal of clinical pharmacology2022
Prevalence and patient-rated relevance of complexity factors in medication regimens of community-dwelling patients with polypharmacy.
Trial report in European journal of clinical pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- What should patients learn? Co-designing patient education to improve medication safety, professional-patient communication, and partnership.Frontiers in medicine · 2025Article
- A Novel Screening Method to Prioritise Cardiovascular Patients Receiving a Pharmaceutical Care Intervention and the Effects on Patients' Difficulties with Managing Their Drug Treatment.Patient preference and adherence · 2025Article
- Potentially Inappropriate Medication: A Pilot Study in Institutionalized Older Adults.Healthcare (Basel, Switzerland) · 2024Article
- Evaluating the Medication Regimen Complexity Score as a Predictor of Clinical Outcomes in the Critically Ill.Journal of clinical medicine · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 4 institutions in 1 country.
Funding
Abstract
purposeTo describe the prevalence of complexity factors in the medication regimens of community-dwelling patients with more than five drugs and to evaluate the relevance of these factors for individual patients.
methodsData were derived from the HIOPP-6 trial, a controlled study conducted in 9 general practices which evaluated an electronic tool to detect and reduce complexity of drug treatment. The prevalence of complexity factors was based on the results of the automated analysis of 139 patients' medication data. The relevance assessment was based on the patients' rating of each factor in an interview (48 patients included for analysis).
resultsA median of 5 (range 0-21) complexity factors per medication regimen were detected and at least one factor was observed in 131 of 139 patients. Almost half of these patients found no complexity factor in their medication regimen relevant.
conclusionIn most medication regimens, complexity factors could be identified automatically, yet less than 15% of factors were indeed relevant for patients as judged by themselves. When assessing complexity of medication regimens, one should especially consider factors that are both particularly frequent and often challenging for patients, such as use of inhalers or tablet splitting.
trial registrationThe HIOPP-6 trial was registered retrospectively on May 17, 2021, in the German Clinical Trials register under DRKS-ID DRKS00025257.
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