Trial reportJournal of applied oral science : revista FOB2022
Preemptive analgesia with ibuprofen increases anesthetic efficacy in children with severe molar: a triple-blind randomized clinical trial.
Trial report in Journal of applied oral science : revista FOB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Effectiveness of different anaesthetic techniques, agents and adjunctive interventions in handling pain during dental treatment of MIH-affected teeth: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Effectiveness of Various Pain Control Methods in Managing MIH-A Systematic Review and Meta-Analysis.International journal of paediatric dentistry · 2026Pooled it
- Evidence mapping and quality assessment of randomised trials related to molar incisor hypomineralisation.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Pooled it
- Ibuprofen for acute postoperative pain in children.The Cochrane database of systematic reviews · 2024Pooled it
- Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.Scientific reports · 2026Trial
- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Long-term evaluation of the success rate of different treatment modalities on MIH-affected teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Salivary Cortisol as a Biomarker for Assessing Fear and Anxiety in Patients with Molar-Incisor Hypomineralization.Diagnostics (Basel, Switzerland) · 2025Article
- Treatment Approaches to Molar Incisor Hypomineralization: A Systematic Review.Journal of clinical medicine · 2023Review
- Association of dental hypersensitivity and anxiety in children with molar-incisor hypomineralisation (MIH).European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
Corrections and comments
- Erratum issuedERRATUM.2022
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molar incisor hypomineralization (MIH) is often accompanied by dental hypersensitivity and difficulty in achieving effective analgesia.
objectiveThis study evaluated the effectiveness of preemptive analgesia in children with severe MIH, post-eruptive enamel breakdown, and hypersensitivity. METHODOLOGY: Ibuprofen (10 mg/kg child weight) or placebo was administered, followed by infiltrative anesthesia and restoration with resin composite. Hypersensitivity was evaluated in five moments. The data were analyzed using the chi-square test, Fisher's exact test, and t-test.
resultsPreemptive analgesia provided benefits for the treatment of severe cases of MIH, with an increase in the effectiveness of infiltrative anesthesia and improved patient comfort during the restorative procedure.
conclusionPreemptive analgesia has shown efficacy in reducing hypersensitivity during restorative dental procedures, evidencing the significance of this study for patients with MIH and hypersensitivity.
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Registered trials
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