Evidence map›Paper›PMID 35475970›Full record

ArticleeLife2022

Allosteric cooperation in β-lactam binding to a non-classical transpeptidase.

Nazia Ahmad, Sanmati Dugad, Varsha Chauhan, Shubbir Ahmed, Kunal Sharma, Sangita Kachhap, Rana Zaidi, William R Bishai, Gyanu Lamichhane, Pankaj Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The l,d-Transpeptidase LdtACS infectious diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Nazia Ahmad *Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard University, Delhi, India.
Sanmati Dugad *Department of Infectious Diseases, Centre for Tuberculosis Research, Johns Hopkins University, Baltimore, United States.
Varsha ChauhanDepartment of Infectious Diseases, Centre for Tuberculosis Research, Johns Hopkins University, Baltimore, United States.
Shubbir AhmedTranslational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, India.
Kunal SharmaDepartment of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard University, Delhi, India.
Sangita Kachhap4Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek, Poland.
Rana ZaidiDepartment of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard University, Delhi, India.
William R BishaiDepartment of Infectious Diseases, Centre for Tuberculosis Research, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-8734-4118
Gyanu LamichhaneDepartment of Infectious Diseases, Centre for Tuberculosis Research, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-2214-0114
Pankaj KumarDepartment of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard University, Delhi, India.ORCID 0000-0001-9163-3273
Johns Hopkins University · USHamdard University · PKJerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences · PLTranslational Health Science and Technology Institute · IN

Funding

A strategy for new regimens to treat pulmonary Mycobacteroides abscessus infectionR01AI155664 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2020 to 2024
$2.1M
Development of an Oral Carbapenem Drug for Treatment of Drug Resistant TBR33AI111739 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LAMICHHANE, GYANU · 2016 to 2018
$1.4M
NIAID NIH HHS R01 AI155664NIAID NIH HHS R33 AI111739
6 · The paper itself

Abstract

L,D-transpeptidase function predominates in atypical 3 → 3 transpeptide networking of peptidoglycan (PG) layer

Indexed as

Mycobacterium tuberculosisPeptidyl TransferasesAnti-Bacterial Agentsbeta-LactamsCatalytic DomainPeptidoglycanAnti-Bacterial Agentsbeta-LactamsPeptidoglycanPeptidyl Transferasesallosterybiochemistrychemical biologyL,D-transpeptidasemolecular biophysicsMycobacterium tuberculosisnonepeptidoglycanstructural biologyβ-lactam

Identifiers

PMID35475970
PMCPMC9094749
OpenAlexW4224983870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.