Evidence map›Paper›PMID 35475912›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Freely available artificial intelligence for pelvic lymph node metastases in PSMA PET-CT that performs on par with nuclear medicine physicians.

Elin Trägårdh, Olof Enqvist, Johannes Ulén, Erland Hvittfeldt, Sabine Garpered, Sarah Lindgren Belal, Anders Bjartell, Lars Edenbrandt

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. coPERCIST: AI-assisted PET-CT response assessment.European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Review
  6. Article
  7. Deep-learning-based software versus experienced nuclear medicine physician to read [European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Review
  9. Article
  10. Artificial intelligence in prostate cancer.Chinese medical journal · 2025
    Review
  11. Review
  12. Article
  13. Clinical value of [Theranostics · 2025
    Article
  14. A convolutional neural network-based system for fully automatic segmentation of whole-body [European journal of nuclear medicine and molecular imaging · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Quantitative [Scientific reports · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Elin TrägårdhDepartment of Translational Medicine and Wallenberg Centre of Molecular Medicine, Lund University, Malmö, Sweden. elin.tragardh@med.lu.se.ORCID 0000-0002-7116-303X
Olof EnqvistEigenvision AB, Malmö, Sweden.
Johannes UlénEigenvision AB, Malmö, Sweden.
Erland HvittfeldtDepartment of Translational Medicine and Wallenberg Centre of Molecular Medicine, Lund University, Malmö, Sweden.
Sabine GarperedDepartment of Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Carl Bertil Laurells gata 9, 205 02, Malmö, Sweden.
Sarah Lindgren BelalDepartment of Translational Medicine and Wallenberg Centre of Molecular Medicine, Lund University, Malmö, Sweden.
Anders BjartellDepartment of Urology, Skåne University Hospital and Lund University, Malmö, Sweden.
Lars EdenbrandtDepartment of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Lund University · SEChalmers University of Technology · SESahlgrenska University Hospital · SESkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to develop and validate an artificial intelligence (AI)-based method using convolutional neural networks (CNNs) for the detection of pelvic lymph node metastases in scans obtained using [

methods[

resultsThe sensitivity of the AI method for detecting pelvic lymph node metastases was 82%, and the corresponding sensitivity for the human readers was 77% on average. The average number of false positives was 1.8 per patient. A total of 5-17 false negative lesions in the whole cohort were found, depending on which reader was used as a reference. The method is available for researchers at www.recomia.org .

conclusionThis study shows that AI can obtain a sensitivity on par with that of physicians with a reasonable number of false positives. The difficulty in achieving high inter-observer sensitivity emphasizes the need for automated methods. On the road to qualifying AI tools for clinical use, independent validation is critical and allows performance to be assessed in studies from different hospitals. Therefore, we have made our AI tool freely available to other researchers.

Indexed as

Nuclear MedicinePhysiciansProstatic NeoplasmsArtificial IntelligenceGallium RadioisotopesHumansLymphatic MetastasisMalePositron Emission Tomography Computed TomographyRadiopharmaceuticalsGallium RadioisotopesRadiopharmaceuticalsArtificial intelligenceConvolutional neural networkDeep learningProstate cancerPSMA

Identifiers

PMID35475912
PMCPMC9308591
OpenAlexW4224944556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.