Evidence map›Paper›PMID 35475787›Full record

ArticleJMIR formative research2022

Live Video Mind-Body Program for Patients With Knee Osteoarthritis, Comorbid Depression, and Obesity: Development and Feasibility Pilot Study.

Ryan A Mace, Jonathan Greenberg, Nicole Lemaster, Brooke Duarte, Terence Penn, Millan Kanaya, James D Doorley, Jessica L Burris, Cale A Jacobs, Ana-Maria Vranceanu

Abstract read
In one paragraph

Article in JMIR formative research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan A MaceIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0001-5738-8606
Jonathan GreenbergIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0002-4875-2207
Nicole LemasterDepartment of Orthopaedic Surgery & Sports Medicine, University of Kentucky, Lexington, KY, United States.ORCID https://orcid.org/0000-0003-4600-6849
Brooke DuarteIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.ORCID https://orcid.org/0000-0002-8732-1768
Terence PennIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0001-9262-2584
Millan KanayaIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States.ORCID https://orcid.org/0000-0003-1538-8012
James D DoorleyIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0001-9080-4915
Jessica L BurrisDepartment of Psychology, University of Kentucky, Lexington, KY, United States.ORCID https://orcid.org/0000-0003-2263-2757
Cale A JacobsDepartment of Orthopaedic Surgery & Sports Medicine, University of Kentucky, Lexington, KY, United States.ORCID https://orcid.org/0000-0002-9300-5550
Ana-Maria VranceanuIntegrated Brain Health Clinical and Research Program, Center for Health Outcomes and Interdisciplinary Research, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID https://orcid.org/0000-0003-3994-6488

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Live video mind-body treatment to prevent persistent symptoms following mTBIK23AT010653 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, JONATHAN · 2020 to 2024
$790k
Development of a Mind Body Program to Reduce Knee Pain in Obese Osteoarthritis Patients with Comorbid DepressionR34AT010370 · NCCIH · UNIVERSITY OF KENTUCKY · PI CONLEY, CAITLIN ELIZABETH-WHALE, VRANCEANU, ANA-MARIA · 2020 to 2022
$739k
NCATS NIH HHS UL1 TR001998NCCIH NIH HHS K23 AT010653NCCIH NIH HHS R34 AT010370
6 · The paper itself

Abstract

backgroundKnee osteoarthritis (KOA) is the most common joint disorder in the United States and a leading cause of disability. Depression and obesity are highly comorbid with KOA and accelerate knee degeneration and disability through biopsychosocial mechanisms. Mind-body physical activity programs can engage biological, mechanical, and psychological mechanisms to improve outcomes in KOA, but such programs are not currently available.

objectiveThis mixed methods study aims to adapt a mind-body activity program for the unique needs of patients with KOA, depression, and obesity (GetActive-OA) delivered via live video.

methodsParticipants were adults (aged ≥45 years) from rural Kentucky with obesity (BMI≥30 kg/m

resultsPhase 1 qualitative analyses revealed nuanced information about challenges with coping and increasing activity, high interest in a mind-body activity program, program participation facilitators (flexibility with technology) and barriers (amotivation and forgetfulness), and perceived challenges with data collection procedures (blood and urine samples and homework). Phase 2 quantitative analyses showed that GetActive-OA met most a priori feasibility markers: acceptability (80%), expectancy (100%), credibility (100%), clinician adherence (90%), homework adherence (80%), questionnaire data collection (100%), program satisfaction (100%), and safety (100%). Adherence to ActiGraph wear (80% baseline, 20% posttest) and collection of blood samples (60%) were low. Participation in GetActive-OA was associated with signals of improvements in general coping (Cohen d=2.41), pain catastrophizing (Cohen d=1.24), depression (Cohen d=0.88), anxiety (Cohen d=0.78), self-efficacy (Cohen d=0.73), pain (Cohen d=0.39), and KOA symptoms (Cohen d=0.36). Qualitative exit interviews confirmed quantitative findings and provided valuable information to optimize the program and protocol.

conclusionsPatients with KOA, depression, and obesity from rural Kentucky were interested in a live video mind-body activity program. GetActive-OA shows promise; however, the program and protocol require further NIH stage I refinement before formal efficacy testing (NIH model stage II). INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.1016/j.conctc.2021.100720.

Indexed as

depressionknee osteoarthritismind-bodymixed-methodsmobile phoneobesityphysical activity

Identifiers

PMID35475787
PMCPMC9096632

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.