Evidence map›Paper›PMID 35475645›Full record

ArticlemBio2022

Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth of Staphylococcus aureus in Defined Medium Lacking Glucose and Arginine.

Itidal Reslane, Cortney R Halsey, Amanda Stastny, Barbara J Cabrera, Jongsam Ahn, Dhananjay Shinde, Madeline R Galac, Margaret F Sladek, Fareha Razvi, McKenzie K Lehman and 4 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Construction of a linezolid-resistant strain of methicillin-susceptibleFrontiers in cellular and infection microbiology · 2026
    Article
  5. ArgT functions as an arginine transporter inJournal of bacteriology · 2025
    Article
  6. Growth and acetate metabolism ofApplied and environmental microbiology · 2025
    Article
  7. High-resolutionMicrobial genomics · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Microbiota and metabolic adaptation shapebioRxiv : the preprint server for biology · 2024
    Article
  14. ThemBio · 2024
    Article
  15. GlutamateJournal of bacteriology · 2024
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Itidal ReslaneUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Cortney R HalseyUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Amanda StastnyUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Barbara J CabreraUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Jongsam AhnUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Dhananjay ShindeUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Madeline R GalacMultidrug-Resistant Organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Margaret F SladekUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Fareha RazviUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
McKenzie K LehmanUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Kenneth W BaylesUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Vinai C ThomasUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.ORCID 0000-0002-7886-0727
Luke D HandkeUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.
Paul D FeyUniversity of Nebraska Medical Centergrid.266813.8, Department of Pathology and Microbiology, Omaha, Nebraska, USA.ORCID 0000-0003-0939-6884
University of Nebraska Medical Center · USWalter Reed Army Institute of Research · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
The role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9M
NIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588
6 · The paper itself

Abstract

Previous studies have found that arginine biosynthesis in Staphylococcus aureus is repressed via carbon catabolite repression (CcpA), and proline is used as a precursor. Unexpectedly, however, robust growth of S. aureus is not observed in complete defined medium lacking both glucose and arginine (CDM-R). Mutants able to grow on agar-containing defined medium lacking arginine (CDM-R) were selected and found to contain mutations within

Indexed as

Ornithine CarbamoyltransferaseStaphylococcus aureusAmino AcidsArginineBacterial ProteinsGlucoseOrnithineAmino AcidsArginineBacterial ProteinsGlucoseOrnithineOrnithine Carbamoyltransferasearginine biosynthesisauxotrophyStaphylococcus aureustranscriptional regulation

Identifiers

PMID35475645
PMCPMC9239276
OpenAlexW4224999554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.