ArticleCancer medicine2022
Disproportionately high failure to rescue rates after resection for colorectal cancer in the geriatric patient population - A nationwide study.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Risk assessment of lymph node metastasis and comparison of treatment modalities for low-risk T1b colorectal cancer: a meta-analysis.Surgical endoscopy · 2025Pooled it
- Evaluation of the safety and efficacy of perform enterectomy in colorectal cancer patients aged 80 or older. A meta-analysis and a systematic review.International journal of colorectal disease · 2023Pooled it
- Postoperative outcomes after inguinal hernia repair in octogenarians in Germany: an exploratory analysis of a retrospective single-centre cohort.Langenbeck's archives of surgery · 2026Article
- Chronological age and failure to rescue after colorectal cancer surgery: A multicentre cohort study.Aging clinical and experimental research · 2026Article
- Outcomes Following Colorectal Cancer Resection in Elderly Patients.Current oncology (Toronto, Ont.) · 2025Article
- Characteristics, Treatment and Outcomes of Stage I to III Colorectal Cancer in Patients Aged over 80 Years Old.Cancers · 2025Article
- Weekday effect of surgery on in-hospital outcome in pancreatic surgery: a population-based study.Langenbeck's archives of surgery · 2024Article
- Association of risk analysis index with 90-day failure to rescue following major abdominal surgery in geriatric patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2024Article
- Risk factors for in-hospital mortality after emergency colorectal surgery in octogenarians: results of a cohort study from a referral center.International journal of colorectal disease · 2023Article
- Surgical treatment and overall survival in patients with right-sided obstructing colon cancer-a nationwide retrospective cohort study.International journal of colorectal disease · 2023Article
- Presentation, Molecular Characteristics, Treatment, and Outcomes of Colorectal Cancer in Patients Older than 80 Years Old.Medicina (Kaunas, Lithuania) · 2023Review
- Clinical outcomes and cost comparison of laparoscopic versus open surgery in elderly colorectal cancer patients over 80 years.International journal of colorectal disease · 2023Article
- The influence of socioeconomic aspects and hospital case volume on survival in colorectal cancer in Saxony, Germany.BMC cancer · 2023Article
- Disproportionately high failure to rescue rates after resection for colorectal cancer in the geriatric patient population - A nationwide study.Cancer medicine · 2022Article
- Robotic-Assisted versus Laparoscopic Left Hemicolectomy-Postoperative Inflammation Status, Short-Term Outcome and Cost Effectiveness.International journal of environmental research and public health · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer incidence increases with patient age. The aim of this study was to assess, at the nationwide level, in-hospital mortality, and failure to rescue in geriatric patients (≥ 80 years old) with colorectal cancer arising from postoperative complications.
methodsAll patients receiving surgery for colorectal cancer in Germany between 2012 and 2018 were identified in a nationwide database. Association between age and in-hospital mortality following surgery and failure to rescue, defined as death after complication, were determined in univariate and multivariate analyses.
resultsThree lakh twenty-eight thousands two hundred and ninety patients with colorectal cancer were included of whom 77,287 were 80 years or older. With increasing age, a significant relative increase in right hemicolectomy was observed. In general, these patients had more comorbid conditions and higher frailty. In-hospital mortality following colorectal cancer surgery was 4.9% but geriatric patients displayed a significantly higher postoperative in-hospital mortality of 10.6%. The overall postoperative complication rate as well as failure to rescue increased with age. In contrast, surgical site infection (SSI) and anastomotic leakage (AL) did not increase in geriatric patients, whereas the associated mortality increased disproportionately (13.3% for SSI and 29.9% mortality for patients with AI, both p < 0.001). Logistic regression analysis adjusting for confounders showed that geriatric patients had almost five-times higher odds for death after surgery than the baseline age group below 60 (OR 4.86; 95%CI [4.45-5.53], p < 0.001).
conclusionGeriatric patients have higher mortality after colorectal cancer surgery. This may be partly due to higher frailty and disproportionately higher rates of failure to rescue arising from postoperative complications.
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