Evidence map›Paper›PMID 35475536›Full record

SynthesisJournal of the American Medical Informatics Association : JAMIA2022

Use of unstructured text in prognostic clinical prediction models: a systematic review.

Tom M Seinen, Egill A Fridgeirsson, Solomon Ioannou, Daniel Jeannetot, Luis H John, Jan A Kors, Aniek F Markus, Victor Pera, Alexandros Rekkas, Ross D Williams and 3 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of the American Medical Informatics Association : JAMIA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Explaining alerts from a pediatric risk prediction model using clinical text.Journal of the American Medical Informatics Association : JAMIA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tom M SeinenDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5369-8260
Egill A FridgeirssonDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Solomon IoannouDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Daniel JeannetotDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Luis H JohnDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jan A KorsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Aniek F MarkusDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Victor PeraDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Alexandros RekkasDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-5352-943X
Ross D WilliamsDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-7723-417X
Cynthia YangDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-6769-3153
Erik M van MulligenDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peter R RijnbeekDepartment of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Funding

European Health Data & Evidence Network (EHDEN)European Health Data & Evidence Network (EHDEN) 806968European Union's Horizon 2020 researchEuropean Union's Horizon 2020 research and innovation program and EFPIAInnovative Medicines Initiative 2 Joint Undertaking (JU) 806968
6 · The paper itself

Abstract

objectiveThis systematic review aims to assess how information from unstructured text is used to develop and validate clinical prognostic prediction models. We summarize the prediction problems and methodological landscape and determine whether using text data in addition to more commonly used structured data improves the prediction performance. MATERIALS AND

methodsWe searched Embase, MEDLINE, Web of Science, and Google Scholar to identify studies that developed prognostic prediction models using information extracted from unstructured text in a data-driven manner, published in the period from January 2005 to March 2021. Data items were extracted, analyzed, and a meta-analysis of the model performance was carried out to assess the added value of text to structured-data models.

resultsWe identified 126 studies that described 145 clinical prediction problems. Combining text and structured data improved model performance, compared with using only text or only structured data. In these studies, a wide variety of dense and sparse numeric text representations were combined with both deep learning and more traditional machine learning methods. External validation, public availability, and attention for the explainability of the developed models were limited.

conclusionThe use of unstructured text in the development of prognostic prediction models has been found beneficial in addition to structured data in most studies. The text data are source of valuable information for prediction model development and should not be neglected. We suggest a future focus on explainability and external validation of the developed models, promoting robust and trustworthy prediction models in clinical practice.

Indexed as

Machine LearningPrognosisclinical prediction modelelectronic health recordsmachine learningnatural language processingprognostic prediction

Identifiers

PMID35475536
PMCPMC9196702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.