Evidence map›Paper›PMID 35475453›Full record

ArticleBioengineered2022

CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis.

Qiao Gu, Wenjie Hou, Lijuan Shi, Zonghao Zhu, Huan Liu, Xiaozhou He

Abstract read
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiao GuDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China.
Wenjie HouDepartment of Gynecology and Obstetrics, Dushu Lake Hospital Affiliated to Soochow University (Medical Center of Soochow University), Suzhou, P.R. China.
Lijuan ShiDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China.
Zonghao ZhuDepartment of Gynecology and Obstetrics, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China.
Huan LiuDepartment of Pathology, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, P.R. China.
Xiaozhou HeDepartment of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CircMCTP2 is a novel circRNA, which is associated with various kinds of malignant tumors progression, such as gastric cancer. However, the function of circMCTP2 in bladder carcinoma (BC) has no idea. The purpose of this study was tantamount to functionally dissect circMCTP2 in the progression of BC. In our study, circMCTP2 expression was strongly increased in BC tissues and cell lines. High expression of circMCTP2 predicted a poor prognosis of BC patients. CircMCTP2 deficiency impaired the cell growth, migration as well as invasive ability of BC cell lines (J82 and T24).

Indexed as

CarcinomaMicroRNAsUrinary Bladder NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceNeoplasm InvasivenessProto-Oncogene Proteins c-mdm2Urinary BladderMicroRNAsMIRN498 microRNA, humanProto-Oncogene Proteins c-mdm2Bladder carcinomacircMCTP2MDM2miR-498

Identifiers

PMID35475453
PMCPMC9208511

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.