ArticleNeuro-oncology advances
Temporal muscle thickness as an independent prognostic imaging marker in newly diagnosed glioblastoma patients: A validation study.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Surgical history and temporal muscle thickness as predictors of successful awake surgery in older patients with glioma.Journal of neuro-oncology · 2026Article
- Temporal muscle measurements as predictor for outcome in a cohort of IDH-wildtype glioblastoma patients.Brain & spine · 2026Article
- Preoperative Temporal Muscle Volume as an Independent Prognostic Marker in Glioblastoma.Cureus · 2025Article
- Two-arm study of sarcopenia in geriatric patients with high-grade glial tumors: temporal muscle thickness and prognostic nutritional index.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Added prognostic value of temporal muscle thickness in glioblastoma with age-stratified analysis.Scientific reports · 2025Article
- IDO2-AhR axis as central regulator of the kynurenine pathway in glioblastoma.Journal of neuro-oncology · 2025Article
- Association of temporalis muscle thickness and frailty in an Australian memory clinic cohort.Aging clinical and experimental research · 2025Article
- Temporal Muscle Thickness as a Prognostic Marker in a Real-Life Cohort of Newly Diagnosed MGMT Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis.Cancer medicine · 2025Article
- Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Age- and sex-adjusted CT-based reference values for temporal muscle thickness, cross-sectional area and radiodensity.Scientific reports · 2025Article
- Prognostic relevance of high expression of kynurenine pathway markers in glioblastoma.Scientific reports · 2024Article
- The relationship between prognosis and temporal muscle thickness in 102 patients with glioblastoma.Scientific reports · 2024Article
- The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis.World neurosurgery: X · 2024Review
- Initial Temporal Muscle Thickness and Area: Poor Predictors of Neurological Outcome in Aneurysmal Subarachnoid Hemorrhage in a Central European Patient Cohort.Journal of clinical medicine · 2023Article
- Correlation between temporal muscle thickness and grip strength in hemiplegic patients with acute stroke.Frontiers in neurology · 2023Article
- Advances in the relationship between temporal muscle thickness and prognosis of patients with glioblastoma: a narrative review.Frontiers in oncology · 2023Review
- Correlation of reduced temporal muscle thickness and systemic muscle loss in newly diagnosed glioblastoma patients.Journal of neuro-oncology · 2022Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Previous studies have recognized temporal muscle thickness (TMT) as a prognostic marker in glioblastoma, but clinical implementation is hampered due to studies' heterogeneity and lack of established cutoff values. The aim of this study was to assess the validity of recent proposed sex-specific TMT cutoff values in a real-world population of genotyped primary glioblastoma patients. Methods: We measured TMT in preoperative MR images of 328 patients. Sex-specific TMT cutoff values were used to divide patients into "at risk of sarcopenia" or "normal muscle status". Kaplan-Meier analyses and stepwise multivariate Cox-Regression analyses were used to assess the association with overall survival (OS) and progression-free survival (PFS). The association with occurrence of complications and discontinuation of glioblastoma treatment was investigated using odds ratios (OR). Results: Patients at risk of sarcopenia had a significantly higher risk of progression and death than patients with normal muscle status, which remained significant in the multivariate analyses (OS HR = 1.437; 95%CI: 1.046-1.973; Conclusions: Our study confirms external validity of the use of proposed sex-specific TMT cutoff values as an independent prognostic marker in newly diagnosed glioblastoma patients. This simple, noninvasive marker could improve patient counseling and aid in treatment decision processes or trial stratification.
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