ArticleAging pathobiology and therapeutics2022
Resilience to aging is a heterogeneous characteristic defined by physical stressors.
Article in Aging pathobiology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Association between physical resilience and self-perceptions of aging among Chinese community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2026Article
- A probabilistic and context-dependent cell culture modelling framework for regulatory toxicology.Frontiers in toxicology · 2026Article
- Resilience and Intrinsic Capacity in Older Adults: A Review of Recent Literature.Journal of clinical medicine · 2025Review
- Plasma longitudinal metabolic changes with acute maximal aerobic exercise and one-hour recovery.Frontiers in molecular biosciences · 2025Article
- Association between atherogenic index of plasma and physical dysfunction: a cross-sectional study of middle-aged and older adults in China.Frontiers in public health · 2025Article
- Article
- Physical Resilience as a Predictor of Lifespan and Late-Life Health in Genetically Heterogeneous Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- Older-aged C57BL/6 mice fed a diet high in saturated fat and sucrose for ten months show decreased resilience to aging.Aging pathobiology and therapeutics · 2023Article
- Is aging "normal"?Aging pathobiology and therapeutics · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Physical resilience, the capacity to respond to and recover from a stressful event, declines with advancing age. Individuals respond differently to physical stressors across their lifespans. While the biological underpinnings of resilience remain unclear, a plausible determinant is the capacity of an individual's cellular and molecular levels to return to homeostasis after a physical challenge. Impaired resilience may not only be a consequence of aging but could also be a contributing factor to the aging process. Therefore, resilience at relatively younger ages could be predictive of future health and lifespan. By utilizing standardized physical challenges and measuring stress response patterns, the relative resilience of individuals can be quantified and classified. Current preclinical research suggests that several physical stressors could be used to measure resilience in clinical aging studies. A mechanistic understanding of why some individuals are more resilient to physical stressors than others could help identify protective factors and therapeutic ways to promote healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.