Evidence map›Paper›PMID 35475166›Full record

ArticleNature reviews. Methods primers2021

Electrolyte-gated transistors for enhanced performance bioelectronics.

Fabrizio Torricelli, Demetra Z Adrahtas, Zhenan Bao, Magnus Berggren, Fabio Biscarini, Annalisa Bonfiglio, Carlo A Bortolotti, C Daniel Frisbie, Eleonora Macchia, George G Malliaras and 7 more

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Engineering two-dimensional electronic biosensors.Nature reviews electrical engineering · 2026
    Article
  6. Article
  7. Article
  8. Optoelectronic Nanofluidic Neural Networks for Ionic Computing.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Broadly applicable hydrophilic additive enhances electrochemical transistor function.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Fabrizio TorricelliDepartment of Information Engineering, University of Brescia, Brescia, Italy.ORCID 0000-0002-7932-0677
Demetra Z AdrahtasDepartment of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4465-9478
Zhenan BaoDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.
Magnus BerggrenLaboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, Sweden.
Fabio BiscariniDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Modena, Italy.
Annalisa BonfiglioDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy.
Carlo A BortolottiDipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Modena, Italy.
C Daniel FrisbieDepartment of Chemical Engineering & Materials Science, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-4735-2228
Eleonora MacchiaFaculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
George G MalliarasElectrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, UK.ORCID 0000-0002-4582-8501
Iain McCullochPhysical Sciences and Engineering Division, KAUST Solar Center (KSC), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.ORCID 0000-0002-6340-7217
Maximilian MoserDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, UK.
Thuc-Quyen NguyenDepartment of Chemistry & Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.
Róisín M OwensDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7856-2108
Alberto SalleoDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Andrea SpanuDepartment of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-0331-7516
Luisa TorsiDepartment of Chemistry, University of Bari 'Aldo Moro', Bari, Italy.ORCID 0000-0002-0798-0780

Funding

TRAINING FOR FUTURE BIOTECHNOLOGY DEVELOPMENTT32GM008347 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SCHMIDT-DANNERT, CLAUDIA · 1990 to 2021
$11.0M
NIGMS NIH HHS T32 GM008347
6 · The paper itself

Abstract

Electrolyte-gated transistors (EGTs), capable of transducing biological and biochemical inputs into amplified electronic signals and stably operating in aqueous environments, have emerged as fundamental building blocks in bioelectronics. In this Primer, the different EGT architectures are described with the fundamental mechanisms underpinning their functional operation, providing insight into key experiments including necessary data analysis and validation. Several organic and inorganic materials used in the EGT structures and the different fabrication approaches for an optimal experimental design are presented and compared. The functional bio-layers and/or biosystems integrated into or interfaced to EGTs, including self-organization and self-assembly strategies, are reviewed. Relevant and promising applications are discussed, including two-dimensional and three-dimensional cell monitoring, ultra-sensitive biosensors, electrophysiology, synaptic and neuromorphic bio-interfaces, prosthetics and robotics. Advantages, limitations and possible optimizations are also surveyed. Finally, current issues and future directions for further developments and applications are discussed.

Identifiers

PMID35475166
PMCPMC9037952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.