ArticleCureus2022
A Case of Refractory Delirium Managed by a Multimodal Approach Using Atypical Antipsychotics, Antidepressants, and Benzodiazepines in an ICU Setting.
Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 citations in OpenAlex.
- The Neuropsychiatric Disturbances of Delirium: A Review of Syndromes and Their Treatment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Review
- Venlafaxine and Delirium: Understanding the Association.Current neuropharmacology · 2026Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delirium is an acute confusional state, most commonly observed in elderly patients admitted to the critical care unit. In most cases, early recognition, avoiding triggering factors and conservative measures are adequate for the management, but sometimes symptoms persist despite adequate medical care, which goes in the favor of refractory delirium. Refractory delirium has no clear-cut definition but it is discussed in some of the case reports and literature as the presence of symptoms despite adequate treatment without impairing consciousness. Management of such refractory symptoms requires careful evaluation to identify the cause and predominant symptoms, which further helps in choosing a better therapeutic regime. It is often difficult to manage such cases and require sedatives and anti-psychotics to reverse the condition. Atypical antipsychotics are now playing a prominent role in the management of refractory delirium, and the selection of a drug that is suitable for the patient profile with negligible side effects is of utmost importance. We are presenting one such case, with multiple causes for his delirium, with a predominant hyperactive state and the refractory symptoms managed by atypical antipsychotics, antidepressants, and benzodiazepines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.