Evidence map›Paper›PMID 35474783›Full record

ArticleACS omega2022

Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using

Shipra Bhatt, Diksha Manhas, Vinay Kumar, Abhishek Gour, Kuhu Sharma, Ashish Dogra, Probir Kumar Ojha, Utpal Nandi

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. Review
  3. Montelukast reduced docetaxel-induced peripheral neuropathy in rats by altering oxidative stress, histopathological damage, and gene expressions.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Cannabidiol-Based Prodrugs: Synthesis and Bioevaluation.ACS medicinal chemistry letters · 2024
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shipra BhattPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Diksha ManhasPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Vinay KumarDrug Theoretics and Chemoinformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Abhishek GourPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Kuhu SharmaPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Ashish DograPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.
Probir Kumar OjhaDrug Theoretics and Chemoinformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Utpal NandiPK-PD Toxicology (PPT) Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.ORCID https://orcid.org/0000-0002-7868-0240
Indian Institute of Integrative Medicine · INJadavpur University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myricetin, a bioflavonoid, is widely used as functional food/complementary medicine and has promising multifaceted pharmacological actions against therapeutically validated anticancer targets. On the other hand, CYP2C8 is not only crucial for alteration in the pharmacokinetics of drugs to cause drug interaction but also unequivocally important for the metabolism of endogenous substances like the formation of epoxyeicosatrienoic acids (EETs), which are considered as signaling molecules against hallmarks of cancer. However, there is hardly any information known to date about the effect of myricetin on CYP2C8 inhibition and, subsequently, the CYP2C8-mediated drug interaction potential of myricetin at the preclinical/clinical level. We aimed here to explore the CYP2C8 inhibitory potential of myricetin using

Identifiers

PMID35474783
PMCPMC9026026
OpenAlexW4223992250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.