Evidence map›Paper›PMID 35474637›Full record

ArticleThe clinical respiratory journal2022

Predictors of malignancy in patients with solitary pulmonary nodules undergoing pulmonary resection.

Eren Erdogdu, Berker Ozkan, Salih Duman, Melek Agkoc, Sukru Mehmet Erturk, Murat Kara, Alper Toker

Open access · goldAbstract read
In one paragraph

Article in The clinical respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Characterization of canine metastatic pulmonary nodules onThe Canadian veterinary journal = La revue veterinaire canadienne · 2025
    Article
  4. Quantitative parameters of HRCT target scan to predict the risk of lung adenocarcinoma based on the detection of lung ground-glass nodules.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Eren ErdogduDepartment of Thoracic Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-8153-0107
Berker OzkanDepartment of Thoracic Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Salih DumanDepartment of Thoracic Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Melek AgkocDepartment of Thoracic Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Sukru Mehmet ErturkDepartment of Radiology, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Murat KaraDepartment of Thoracic Surgery, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Alper TokerDepartment of Cardiovascular and Thoracic Surgery, West Virginia University Heart and Vascular Institute, Morgantown, West Virginia, USA.
Istanbul University · TRWest Virginia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe management of a solitary pulmonary nodule is a challenging issue in pulmonary disease. Although many factors have been defined as predictors for malignancy in solitary pulmonary nodules, the accurate diagnosis can only be established with the permanent histological diagnosis.

objectiveWe tried to clarify the possible predictors of malignancy in solitary pulmonary nodules in patients who had definitive histological diagnosis.

methodsWe made a retrospective study to collect the data of patients with solitary pulmonary nodules who had histological diagnosis either before or after surgery. We made a statistical analysis of both the clinic and radiological features of these nodules with respect to malignancy both in contingency tables and with logistic regression analysis.

resultsWe had a total of 223 patients with a radiological diagnosis of solitary pulmonary nodule. Age, smoking status and pack years of smoking, maximum standardized uptake value (SUVmax), and radiological features such as solid component, spiculation, pleural tag, lobulation, calcification, and higher density were significant predictors of malignancy in contingency tables. Age, smoking status and smoking (pack/year), SUVmax, and radiological features including spiculation, pleural tag, lobulation, calcification, and higher density were the significant predictors in univariate analysis. However, multivariate analysis revealed only SUVmax greater than 2.5 (p < 0.0001), spiculation (p = 0.009), and age older than 61 years (p = 0.015) as the significant predictors for malignancy.

conclusionAge, SUVmax, and spiculation are the independent predictors of malignancy in patients with solitary pulmonary nodules.

Indexed as

Pulmonary Surgical ProceduresAge FactorsHumansLogistic ModelsLung NeoplasmsMiddle AgedPleuraRetrospective StudiesSolitary Pulmonary Nodulelung carcinomamalignancypredictorsolitary pulmonary nodule

Identifiers

PMID35474637
PMCPMC9366584
OpenAlexW4224947661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.