Evidence map›Paper›PMID 35474500›Full record

ReviewCancer metastasis reviews2022

The cure from within? a review of the microbiome and diet in melanoma.

Priyanka Kumar, Danielle Brazel, Julia DeRogatis, Jennifer B Goldstein Valerin, Katrine Whiteson, Warren A Chow, Roberto Tinoco, Justin T Moyers

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer metastasis reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Tumor Microenvironment in Melanoma-Characteristic and Clinical Implications.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priyanka Kumar *Department of Medicine, University of California Irvine, Orange, CA, USA.ORCID 0000-0002-6166-7090
Danielle Brazel *Department of Medicine, University of California Irvine, Orange, CA, USA.ORCID 0000-0001-6178-3895
Julia DeRogatis *Department of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA, USA.ORCID 0000-0002-1744-405X
Jennifer B Goldstein ValerinDivision of Hematology and Oncology, Department of Medicine, University of California Irvine, 101 The City Drive South, Building 200, Orange, CA, 92868, USA.ORCID 0000-0002-0577-7746
Katrine WhitesonDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA, USA.ORCID 0000-0002-5423-6014
Warren A ChowDivision of Hematology and Oncology, Department of Medicine, University of California Irvine, 101 The City Drive South, Building 200, Orange, CA, 92868, USA.ORCID 0000-0003-0889-5841
Roberto TinocoDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California, Irvine, CA, USA.ORCID 0000-0001-5420-9692
Justin T MoyersDivision of Hematology and Oncology, Department of Medicine, University of California Irvine, 101 The City Drive South, Building 200, Orange, CA, 92868, USA. moyersj@hs.uci.edu.ORCID 0000-0001-5139-1652

Funding

CARCINOGENESIST32CA009054 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI EDINGER, AIMEE L, FRUMAN, DAVID ALEXANDER · 1985 to 2025
$8.6M
Host nutrients permit immune evasion of NKT cell anti-bacterial responsesR01AI137230 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2018 to 2022
$3.1M
PSGL-1 mechanisms of T cell exhaustionR01AI137239 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI TINOCO, ROBERTO · 2019 to 2024
$2.1M
NCI NIH HHS T32 CA009054NIAID NIH HHS R01 AI137230NIAID NIH HHS R01 AI137239
6 · The paper itself

Abstract

Therapy for cutaneous melanoma, the deadliest of the skin cancers, is inextricably linked to the immune system. Once thought impossible, cures for metastatic melanoma with immune checkpoint inhibitors have been developed within the last decade and now occur regularly in the clinic. Unfortunately, half of tumors do not respond to checkpoint inhibitors and efforts to further exploit the immune system are needed. Tantalizing associations with immune health and gut microbiome composition suggest we can improve the success rate of immunotherapy. The gut contains over half of the immune cells in our bodies and increasingly, evidence is linking the immune system within our gut to melanoma development and treatment. In this review, we discuss the importance the skin and gut microbiome may play in the development of melanoma. We examine the differences in the microbial populations which inhabit the gut of those who develop melanoma and subsequently respond to immunotherapeutics. We discuss the role of dietary intake on the development and treatment of melanoma. And finally, we review the landscape of published and registered clinical trials therapeutically targeting the microbiome in melanoma through dietary supplements, fecal microbiota transplant, and microbial supplementation.

Indexed as

MelanomaMicrobiotaSkin NeoplasmsDietHumansImmunotherapyCheckpoint inhibitorsCutaneous melanomaImmunotherapyMetastatic melanomaMicrobiome

Identifiers

PMID35474500
PMCPMC9042647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.