Evidence map›Paper›PMID 35474403›Full record

ArticleJournal of youth and adolescence2022

Hypothalamic-pituitary-adrenal Axis Multilocus Genetic Variation, Childhood Parenting and Adolescent Anxiety Symptoms: Evidence of Cumulative Polygenic Plasticity.

Cong Cao, Shan Yang, Kexin Sun, Junlian Gu

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of youth and adolescence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cong CaoSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China. caocong@sdu.edu.cn.
Shan YangSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China.
Kexin SunSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China.
Junlian GuSchool of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shandong University · CN

Funding

National Natural Science Foundation of China 31800936Natural Science Foundation of Shandong Province ZR2019BC111Social Science Planning Fund of Shandong Province 18DJYJ01
6 · The paper itself

Abstract

Research suggests that genetic variants that regulate the hypothalamic-pituitary-adrenal (HPA) axis function moderate the association between parenting and anxiety symptoms, but these studies have primarily focused on (i) individual genes with very small and unreliable effect and (ii) the role of mothers as opposed to fathers. Using a multilocus genetic profile score approach, the current study is the first to examine the moderation effect of HPA-axis multilocus genetic variants on the associations of both maternal and paternal parenting with adolescent anxiety symptoms. In a sample of Chinese Han adolescents (N = 772; 50.1% girls; M

Indexed as

AnxietyHypothalamo-Hypophyseal SystemParentingPituitary-Adrenal SystemAdolescentFemaleGenetic VariationHumansHydrocortisoneMaleMultifactorial InheritanceStress, PsychologicalYoung AdultHydrocortisoneAnxiety symptomsGene-environment interactionHypothalamic-pituitary-adrenal axisInfluence statisticMultilocus genetic profile scorePaternal parenting

Identifiers

PMID35474403
OpenAlexW4224989392

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.