ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022
Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Rheological Modeling to Assess the Gelation Kinetics of Mono- and Multicomponent Supramolecular Hydrogels.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Self-Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide-Based Hydrogels.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Morphology and Applications of Self-Assembled Peptide Nucleic Acids.International journal of molecular sciences · 2024Review
- Tryptophan-PNA gc Conjugates Self-Assemble to Form Fibers.Bioconjugate chemistry · 2023Article
- Chiral Fibers Formation Upon Assembly of Tetraphenylalanine Peptide Conjugated to a PNA Dimer.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembly of biomolecules such as peptides, nucleic acids or their analogues affords supramolecular objects, exhibiting structures and physical properties dependent on the amino-acid or nucleobase composition. Conjugation of the peptide diphenylalanine (FF) to peptide nucleic acids triggers formation of self-assembled structures, mainly stabilized by interactions between FF. In this work we report formation of homogeneous chiral fibers upon self-assembly of the hybrid composed of the tetraphenylalanine peptide (4F) conjugated to the PNA dimer adenine-thymine (at). In this case nucleobases seem to play a key role in determining the morphology and chirality of the fibers. When the PNA "at" is replaced by guanine-cytosine dimer "gc", disordered structures are observed. Spectroscopic characterization of the self-assembled hybrids, along with AFM and SEM studies is reported. Finally, a structural model consistent with the experimental evidence has also been obtained, showing how the building blocks of 4Fat arrange to give helical fibers.
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