ReviewExperimental & molecular medicine2022
Role of the gut-brain axis in energy and glucose metabolism.
Review in Experimental & molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it, 227 citations in OpenAlex.
- The Role of Short-Chain Fatty Acids in Microbiota-Gut-Brain Cross-Talk with a Focus on Amyotrophic Lateral Sclerosis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Safety, feasibility, and dose-dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof-of-concept studies.Diabetes, obesity & metabolism · 2026Trial
- A personalized plant-rich, time-restricted nutritional intervention for motor and non-motor symptoms in Parkinson's disease: A randomized controlled trial.Journal of Parkinson's disease · 2026Trial
- Trial
- Schizophrenia-associated gut microbiota are linked to reduced colonic PRODH expression and behavioral changes in mice.Gut microbes · 2026Article
- Cholecystokinin Induces CaThe European journal of neuroscience · 2026Article
- Seasonal Variation of Gut Bacterial Community in WildEcology and evolution · 2026Article
- The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut-brain axis.Translational neurodegeneration · 2026Review
- Endogenous Lipid Signals in Energy Homeostasis and Fibrosis.Biomolecules · 2026Review
- Metabolomic insights into the response strategies of bats to high-glucose stimulation.Zoological research · 2026Article
- KBN2201 Attenuates High-Fat Diet-Induced Adipose Tissue Expansion and Body Weight Gain in Male Mice.International journal of molecular sciences · 2026Article
- Tirzepatide as a multi-organ integrator in metabolic diseases: a review of molecular mechanisms and clinical translation.Endocrine · 2026Review
- Plant-Derived Foods and Medicines as Modulators of the Gut Microbiome: Molecular Interactions and Implications for Disease and Therapy.Molecules (Basel, Switzerland) · 2026Review
- Pan-tissue transcriptomic profiling of dairy cattle.Journal of animal science and biotechnology · 2026Article
- The vagus nerve promotes memory in rats via nutrient-induced septo-hippocampal acetylcholine signaling.Nature communications · 2026Article
- AgRP neuron activity predicts and tracks the glycemic response to oral glucose.Molecular metabolism · 2026Article
- Targeted Magnetic Nanodiscs for Wireless Causal Manipulation of Gut-Brain Circuits.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of weight recurrence after bariatric surgery.Nutrition & metabolism · 2026Review
- Regional and Systemic Metabolic Remodeling Promotes Longevity by Bioengineered Yeast-Derived Lipids.bioRxiv : the preprint server for biology · 2026Article
- AgRP Neuron Activity Predicts and Tracks the Glycemic Response to Oral Glucose.bioRxiv : the preprint server for biology · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gastrointestinal tract plays a role in the development and treatment of metabolic diseases. During a meal, the gut provides crucial information to the brain regarding incoming nutrients to allow proper maintenance of energy and glucose homeostasis. This gut-brain communication is regulated by various peptides or hormones that are secreted from the gut in response to nutrients; these signaling molecules can enter the circulation and act directly on the brain, or they can act indirectly via paracrine action on local vagal and spinal afferent neurons that innervate the gut. In addition, the enteric nervous system can act as a relay from the gut to the brain. The current review will outline the different gut-brain signaling mechanisms that contribute to metabolic homeostasis, highlighting the recent advances in understanding these complex hormonal and neural pathways. Furthermore, the impact of the gut microbiota on various components of the gut-brain axis that regulates energy and glucose homeostasis will be discussed. A better understanding of the gut-brain axis and its complex relationship with the gut microbiome is crucial for the development of successful pharmacological therapies to combat obesity and diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.