Evidence map›Paper›PMID 35474242›Full record

ArticleScientific reports2022

A preclinical radiotherapy dosimetry audit using a realistic 3D printed murine phantom.

Emma R Biglin, Adam H Aitkenhead, Gareth J Price, Amy L Chadwick, Elham Santina, Kaye J Williams, Karen J Kirkby

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma R BiglinDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK. Emma.biglin@postgrad.manchester.ac.uk.ORCID http://orcid.org/0000-0003-3333-5037
Adam H AitkenheadDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.
Gareth J PriceDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.
Amy L ChadwickDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.ORCID http://orcid.org/0000-0002-7841-0507
Elham SantinaDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.
Kaye J WilliamsDivision of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Karen J KirkbyDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, 3rd floor Proton Beam Therapy Centre, Oak Road, Manchester, M20 4BX, UK.

Funding

Cancer Research UK 28701Cancer Research UK C147/A25254Cancer Research UK C1994/A28701Department of Health
6 · The paper itself

Abstract

Preclinical radiation research lacks standardized dosimetry procedures that provide traceability to a primary standard. Consequently, ensuring accuracy and reproducibility between studies is challenging. Using 3D printed murine phantoms we undertook a dosimetry audit of Xstrahl Small Animal Radiation Research Platforms (SARRPs) installed at 7 UK centres. The geometrically realistic phantom accommodated alanine pellets and Gafchromic EBT3 film for simultaneous measurement of the dose delivered and the dose distribution within a 2D plane, respectively. Two irradiation scenarios were developed: (1) a 10 × 10 mm

Indexed as

Printing, Three-DimensionalRadiometryAlanineAnimalsMicePhantoms, ImagingReproducibility of ResultsAlanine

Identifiers

PMID35474242
PMCPMC9042835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.