ArticleNPJ Regenerative medicine2022
Biomechanically and biochemically functional scaffold for recruitment of endogenous stem cells to promote tendon regeneration.
Article in NPJ Regenerative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
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Who cites it
18 citing papers in PubMed.
- Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review.Advanced healthcare materials · 2026Review
- Efficacy of Human Tendon-Derived Extracellular Matrix in Achilles Tendon Regeneration.Journal of clinical medicine · 2026Article
- Recent advances in immunoregulatory biomaterials for tendon healing: From immune remodeling to functional regeneration.Materials today. Bio · 2026Review
- Grafts in tendon repair.Materials today. Bio · 2026Review
- Bioinspired Nanocomposite for Targeted Immunoengineering and Improved Tendon Regeneration.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Advanced bioactive materials and strategies for tendon repair and function restoration.Journal of orthopaedic translation · 2025Review
- Implications of Tissue Engineering for Tendon Repair and Regeneration.Journal of functional biomaterials · 2025Review
- Inflammatory factors released by ACL reconstruction tendon grafts and their potential for macrophage polarization.Scientific reports · 2025Article
- Research Progress on the Preparation and Application of Decellularized Tendons.Current issues in molecular biology · 2025Review
- Crafting the future of bone regeneration: the promise of supramolecular peptide nanofiber hydrogels.Frontiers in bioengineering and biotechnology · 2025Review
- Extracellular matrix-derived materials for tissue engineering and regenerative medicine: A journey from isolation to characterization and application.Bioactive materials · 2024Review
- Bioactive Materials That Promote the Homing of Endogenous Mesenchymal Stem Cells to Improve Wound Healing.International journal of nanomedicine · 2024Review
- Dendritic Cell-Derived Exosomes Promote Tendon Healing and Regulate Macrophage Polarization in Preventing Tendinopathy.International journal of nanomedicine · 2024Article
- Some Mechanical Constraints to the Biomimicry with Peripheral Nerves.Biomimetics (Basel, Switzerland) · 2023Article
- Growth factors in the treatment of Achilles tendon injury.Frontiers in bioengineering and biotechnology · 2023Review
- The Functions and Mechanisms of Tendon Stem/Progenitor Cells in Tendon Healing.Stem cells international · 2023Review
- 3D printing of injury-preconditioned secretome/collagen/heparan sulfate scaffolds for neurological recovery after traumatic brain injury in rats.Stem cell research & therapy · 2022Article
- Decellularized Extracellular Matrix-Based Bioinks for Tendon Regeneration in Three-Dimensional Bioprinting.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined the decellularized bovine tendon sheet (DBTS) with extracellular matrix (ECM) from tendon-derived stem cells (TDSCs) to fabricate a biomechanically and biochemically functional scaffold (tECM-DBTS), to provide a functional and stem cell ECM-based microenvironment for tendon regeneration. Our prior study showed that DBTS was biomechanically suitable to tendon repair. In this study, the biological function of tECM-DBTS was examined in vitro, and the efficiency of the scaffold for Achilles tendon repair was evaluated using immunofluorescence staining, histological staining, stem cell tracking, biomechanical and functional analyses. It was found that tECM-DBTS increased the content of bioactive factors and had a better performance for the proliferation, migration and tenogenic differentiation of bone marrow-derived stem cells (BMSCs) than DBTS. Furthermore, our results demonstrated that tECM-DBTS promoted tendon regeneration and improved the biomechanical properties of regenerated Achilles tendons in rats by recruiting endogenous stem cells and participating in the functionalization of these stem cells. As a whole, the results of this study demonstrated that the tECM-DBTS can provide a bionic microenvironment for recruiting endogenous stem cells and facilitating in situ regeneration of tendons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.