ArticleNature communications2022
Engineering artificial photosynthetic life-forms through endosymbiosis.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophages.Science advances · 2026Article
- Cross-scale design of abiotic-biotic interfaces for semi-artificial photosynthesis.Chemical science · 2026Review
- Endosymbiotic interactions in the fungal kingdom: a framework for progressive endosymbiosis.Frontiers in microbiology · 2026Review
- Mitochondrial and photosynthetic therapy: A crucial strategy for remodeling cellular metabolic function.Bioengineering & translational medicine · 2025Review
- Molecular and biochemical insights from natural and engineered photosynthetic endosymbiotic systems.Current opinion in chemical biology · 2025Review
- Artificial Endosymbiosis of Pedobacter sp. DDGJ Boosts the Growth Potential, Stress Resistance and Productivity of Morchella Mushrooms.Microbial biotechnology · 2025Article
- Article
- Cell-Free Systems to Mimic and Expand Metabolism.ACS synthetic biology · 2025Review
- A new-to-nature photosynthesis system enhances utilization of one-carbon substrates in Escherichia coli.Nature communications · 2025Article
- Photosynthetic directed endosymbiosis to investigate the role of bioenergetics in chloroplast function and evolution.Nature communications · 2024Article
- Engineering signalling pathways in mammalian cells.Nature biomedical engineering · 2024Review
- Article
- Introducing carbon assimilation in yeasts using photosynthetic directed endosymbiosis.Nature communications · 2024Article
- Evolution and synthetic biology.Current opinion in microbiology · 2023Review
- A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast.Nature communications · 2023Review
- Plant biomacromolecule delivery methods in the 21st century.Frontiers in genome editing · 2022Review
- Biosynthetic approaches to efficient assimilation of COFrontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The evolutionary origin of the photosynthetic eukaryotes drastically altered the evolution of complex lifeforms and impacted global ecology. The endosymbiotic theory suggests that photosynthetic eukaryotes evolved due to endosymbiosis between non-photosynthetic eukaryotic host cells and photosynthetic cyanobacterial or algal endosymbionts. The photosynthetic endosymbionts, propagating within the cytoplasm of the host cells, evolved, and eventually transformed into chloroplasts. Despite the fundamental importance of this evolutionary event, we have minimal understanding of this remarkable evolutionary transformation. Here, we design and engineer artificial, genetically tractable, photosynthetic endosymbiosis between photosynthetic cyanobacteria and budding yeasts. We engineer various mutants of model photosynthetic cyanobacteria as endosymbionts within yeast cells where, the engineered cyanobacteria perform bioenergetic functions to support the growth of yeast cells under defined photosynthetic conditions. We anticipate that these genetically tractable endosymbiotic platforms can be used for evolutionary studies, particularly related to organelle evolution, and also for synthetic biology applications.
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