Evidence map›Paper›PMID 35474064›Full record

ArticleNature communications2022

Mesoscopic landscape of cortical functions revealed by through-skull wide-field optical imaging in marmoset monkeys.

Xindong Song, Yueqi Guo, Hongbo Li, Chenggang Chen, Jong Hoon Lee, Yang Zhang, Zachary Schmidt, Xiaoqin Wang

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  4. Neural Recording Chambers for Long-Term Access to Brain Tissue.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Unique Cortical and Subcortical Activation Patterns for Different Conspecific Calls in Marmosets.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. An open access resource for marmoset neuroscientific apparatus.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Acute Neuropixels recordings in the marmoset monkey.bioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xindong SongLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. songxindong@jhmi.edu.ORCID 0000-0002-1388-0524
Yueqi GuoLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Hongbo LiLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Chenggang ChenLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jong Hoon LeeLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Yang ZhangLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.ORCID 0000-0003-3383-7889
Zachary SchmidtLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Xiaoqin WangLaboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA. xiaoqin.wang@jhu.edu.ORCID 0000-0002-3999-0772
Johns Hopkins University · US

Funding

NEURAL BASIS OF COMMUNICATION SOUND PERCEPTIONR01DC003180 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI WANG, XIAOQIN · 1997 to 2024
$12.0M
Auditory-Vocal Interaction Mechanisms in PrimatesR01DC005808 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI WANG, XIAOQIN · 2003 to 2022
$8.0M
NIDCD NIH HHS R01 DC003180NIDCD NIH HHS R01 DC005808
6 · The paper itself

Abstract

The primate cerebral cortex is organized into specialized areas representing different modalities and functions along a continuous surface. The functional maps across the cortex, however, are often investigated a single modality at a time (e.g., audition or vision). To advance our understanding of the complex landscape of primate cortical functions, here we develop a polarization-gated wide-field optical imaging method for measuring cortical functions through the un-thinned intact skull in awake marmoset monkeys (Callithrix jacchus), a primate species featuring a smooth cortex. Using this method, adjacent auditory, visual, and somatosensory cortices are noninvasively parcellated in individual subjects with detailed tonotopy, retinotopy, and somatotopy. An additional pure-tone-responsive tonotopic gradient is discovered in auditory cortex and a face-patch sensitive to motion in the lower-center visual field is localized near an auditory region representing frequencies of conspecific vocalizations. This through-skull landscape-mapping approach provides new opportunities for understanding how the primate cortex is organized and coordinated to enable real-world behaviors.

Indexed as

Auditory CortexCallithrixAnimalsAuditory PerceptionHumansOptical ImagingSkull

Identifiers

PMID35474064
PMCPMC9042927
OpenAlexW4224980343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.