ArticleScientific reports2022
Myocardial work index during normal dobutamine stress echocardiography.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Non-invasive myocardial work analysis in normal, at-risk for heart failure and heart failure patients during stress testing-a systematic review: a joint session with the Romanian Society of Cardiology (part III).Heart failure reviews · 2026Pooled it
- Clinical significance of resting and dobutamine stress myocardial work in cirrhotic cardiomyopathy.Echo research and practice · 2026Article
- DOX-Induced Myopathy and Diastolic Stiffness of the Left Ventricular Myocardium of Rat Heart under Conditions of Dobutamine Load.Bulletin of experimental biology and medicine · 2025Article
- Reserve of global constructive work for early diagnosis of myocardial ischemia and risk stratification in chronic coronary syndrome.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dobutamine stress echocardiography is an alternative method to exercise stress echocardiography for the evaluation of ischemia. Recently, the novel speckle tracking imaging derived parameter, myocardial work index, was suggested for the evaluation of cardiac performance and was evaluated during exercise stress echocardiography. In this study, we analyzed the effect of dobutamine on myocardial work index variables during normal dobutamine stress echocardiography. Echocardiography examinations of patients with normal dobutamine stress echocardiography were collected and underwent off-line speckle tracking imaging analysis. Myocardial work index parameters were calculated at each dose of dobutamine and compared. 286 patients underwent dobutamine stress echocardiography during the study period. 102 patients were excluded due to pre-existed coronary artery disease or ischemia at dobutamine stress echocardiography. 65 patients were excluded due to suboptimal image quality unsuitable for speckle tracking imaging analysis. The remaining 119 patients with normal results were included. The global work index decreased from 2393.3 to 1864.7 mmHg%, p < 0.0004. Global constructive work decreased from 2681.7 to 2152.6 mmHg%, p = 0.001. Global wasted work increased from 78.8 to 128.3 mmHg%, p < 0.003. Global work efficacy decreased from 96.1 to 91.9%, p < 0.00001. Global strain increased from-19.6 to - 23.7%, p < 0.00001. Dobutamine stress echocardiography results in a decrease of all specific myocardial work index parameters even in normal subjects. Only global myocardial strain improved.
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