ArticleNature communications2022
Identifying the wide diversity of extraterrestrial purine and pyrimidine nucleobases in carbonaceous meteorites.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 150 citations in OpenAlex.
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- Distribution of extraterrestrial nucleobases, other N-heterocycles, and their precursors in a sample from asteroid Bennu.Communications chemistry · 2026Article
- Abiotic formation of nitrile precursors to amino acids and nucleobases in interstellar ice analogues.Chemical science · 2026Article
- Space ionizing radiation triggers the formation of peptides and organophosphates on olivine surfaces.Nature communications · 2026Article
- How Does Adenine Form from Hydrogen Cyanide?Journal of the American Chemical Society · 2026Article
- Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World.Life (Basel, Switzerland) · 2026Review
- Abiotic sugar enantiomers in the CI carbonaceous chondrite Orgueil.Nature communications · 2026Article
- Before LUCA: unearthing the chemical roots of metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
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- Abundant ammonia and nitrogen-rich soluble organic matter in samples from asteroid (101955) Bennu.Nature astronomy · 2025Article
- The HOMO-LUMO Gap as Discriminator of Biotic from Abiotic Chemistries.Life (Basel, Switzerland) · 2024Article
- Breunnerite grain and magnesium isotope chemistry reveal cation partitioning during aqueous alteration of asteroid Ryugu.Nature communications · 2024Article
- Effect of Nitrogen on the Structure and Composition of Primordial Organic Matter Analogs.ACS earth & space chemistry · 2024Article
- Microwave-assisted synthesis and functionalization of 2-arylimidazo[1,2-RSC advances · 2024Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
The lack of pyrimidine diversity in meteorites remains a mystery since prebiotic chemical models and laboratory experiments have predicted that these compounds can also be produced from chemical precursors found in meteorites. Here we report the detection of nucleobases in three carbonaceous meteorites using state-of-the-art analytical techniques optimized for small-scale quantification of nucleobases down to the range of parts per trillion (ppt). In addition to previously detected purine nucleobases in meteorites such as guanine and adenine, we identify various pyrimidine nucleobases such as cytosine, uracil, and thymine, and their structural isomers such as isocytosine, imidazole-4-carboxylic acid, and 6-methyluracil, respectively. Given the similarity in the molecular distribution of pyrimidines in meteorites and those in photon-processed interstellar ice analogues, some of these derivatives could have been generated by photochemical reactions prevailing in the interstellar medium and later incorporated into asteroids during solar system formation. This study demonstrates that a diversity of meteoritic nucleobases could serve as building blocks of DNA and RNA on the early Earth.
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