Evidence map›Paper›PMID 35473826›Full record

ArticleBMJ open diabetes research & care2022

Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure than men, with a significant gender interaction between heart failure risk and risk factor management: a retrospective registry study.

Yuko Fujita, Takeshi Morimoto, Akihiro Tokushige, Masayuki Ikeda, Michio Shimabukuro, Koichi Node, Shinichiro Ueda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open diabetes research & care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yuko FujitaDepartment of Clinical Research and Management, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Takeshi MorimotoDepartment of Clinical Epidemiology, Hyogo College of Medicine, Hyogo, Japan.
Akihiro TokushigeDepartment of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Masayuki IkedaDepartment of Medical Informatics, Kagawa University Hospital, Kagawa, Japan.
Michio ShimabukuroDepartment of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, Fukushima, Japan.ORCID 0000-0001-7835-7665
Koichi NodeDepartment of Cardiology, Saga University School of Medicine, Saga, Japan.
Shinichiro UedaDepartment of Clinical Research and Management, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan blessyou@med.u-ryukyu.ac.jp.ORCID 0000-0001-8133-9361
University of the Ryukyus · JPFukushima Medical University · JPHyogo Medical University · JPKagawa University Hospital · JPSaga University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWomen are generally perceived to have a lower risk of cardiovascular events than men, despite a lack of data, particularly among patients with diabetes. Here, we investigated gender differences in the risk of heart failure (HF) events in patients with type 2 diabetes and coronary artery disease (CAD). We also assessed the association between cardiovascular risk factor management and HF events. RESEARCH DESIGN AND

methodsThis retrospective registry study enrolled consecutive patients with both type 2 diabetes and CAD, based on angiography records and medical charts at 70 teaching hospitals in Japan, from January 2005 to December 2015.

resultsThe registry included 7785 patients with a mean follow-up period of 1328 days. The mean age of the patients was 67.6 years. The risk of hospitalization for HF in patients with both type 2 diabetes and CAD was significantly higher among women than among men (HR, 1.26, 95% CI 1.06 to 1.50). The relationship between HF risk and achieved low-density lipoprotein cholesterol (LDL-c) and systolic blood pressure, but not hemoglobin A

conclusionsWomen with type 2 diabetes and CAD have a higher risk of HF than men. A significant gender interaction was observed in the association between HF risk and risk factor management, particularly regarding LDL-c and systolic blood pressure. The effectiveness of risk factor management may differ between men and women regarding HF prevention among patients with type 2 diabetes and CAD.

Indexed as

Coronary Artery DiseaseDiabetes Mellitus, Type 2Heart FailureAgedCholesterol, LDLFemaleHumansMaleRegistriesRetrospective StudiesRisk FactorsCholesterol, LDLDiabetes Mellitus, Type 2Heart FailureSex Characteristics

Identifiers

PMID35473826
PMCPMC9045107
OpenAlexW4224991342

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.