Evidence map›Paper›PMID 35473701›Full record

ArticleBMJ case reports2022

Elevated HCG and retroperitoneal adenopathy after clomiphene therapy for infertility.

Raj Vikesh Tiwari, Maria Di Jiang, Keith Jarvi, Robert Hamilton

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raj Vikesh TiwariUrology, University of Toronto, Toronto, Ontario, Canada raj.tiwari@uhn.ca.ORCID http://orcid.org/0000-0003-3893-5859
Maria Di JiangMedical Oncology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada.
Keith JarviDivision of Urology, Sinai Health System, Toronto, Ontario, Canada.
Robert HamiltonDivision of Urology, University Health Network, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the context of an elevated human chorionic gonadotropin (HCG) with enlarged retroperitoneal nodes and absent testicular tumours, clinicians will consider a diagnosis of extragonadal germ cell tumours. We report the case of a man in his thirties who while on treatment for subfertility with clomiphene citrate was noted to have enlarged retroperitoneal nodes and elevated HCG levels of 75 IU/L. Chemotherapy with bleomycin, etoposide and cisplatin originally planned was deferred when two separate retroperitoneal nodal biopsies returned as benign fibroadipose tissue and HCG levels spontaneously down-trended to 4 IU/L within 4 months of clomiphene citrate discontinuation. Follow-up imaging revealed regression of the retroperitoneal nodes.

Indexed as

InfertilityLymphadenopathyNeoplasms, Germ Cell and EmbryonalTesticular NeoplasmsClomipheneHumansMaleClomipheneDrugs: endocrine systemObstetrics, gynaecology and fertilitySurgical oncologyUrinary and genital tract disordersUrological cancer

Identifiers

PMID35473701
PMCPMC9045039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.