Evidence map›Paper›PMID 35473503›Full record

ArticleBioengineered2022

Curcumin relieved the rheumatoid arthritis progression via modulating the linc00052/miR-126-5p/PIAS2 axis.

Jianwei Xiao, Xu Cai, Weijian Zhou, Rongsheng Wang, Zhizhong Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Review
  5. Article
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  10. Article
  11. The Effects of Curcumin on Inflammasome: Latest Update.Molecules (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jianwei XiaoDepartment of Rheumatology and Immunology, Shenzhen Futian Hospital for Rheumatic Diseases, No.22 Nonglin Road, Shenzhen 518000, China.
Xu CaiDepartment of Rheumatology and Immunology, Shenzhen Futian Hospital for Rheumatic Diseases, No.22 Nonglin Road, Shenzhen 518000, China.
Weijian ZhouDepartment of Rheumatism, Yunnan Provincial Hospital of Traditional Chinese Medicine. NO.120 Guanghua Street, Wuhua District, Kunming City, Yunnan Province, 650000, China.
Rongsheng WangDepartment of Rheumatism, Shanghai Guanghua Hospital of Integrated Traditional and Western Medicine, Shanghai, 200052, China.
Zhizhong YeDepartment of Rheumatology and Immunology, Shenzhen Futian Hospital for Rheumatic Diseases, No.22 Nonglin Road, Shenzhen 518000, China.
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine · CNYunnan Provincial Hospital of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin, with its antioxidant, anti-inflammatory, and antitumor properties, is widely used in the treatment of bone disorders, including rheumatoid arthritis (RA). We investigated the effects of curcumin on fibroblast-like synoviocytes in RA and its underlying mechanism. mRNA and microRNA (miRNA) expression levels were determined using reverse transcription-quantitative polymerase chain reaction. Cellular functions were detected using cell counting kit-8, 5-ethynyl-2'-deoxyuridine, Transwell, and flow cytometric assays. Enzyme-linked immunosorbent assay was performed to measure the cytokine release. Western blotting was used to determine the protein expression levels. An

Indexed as

Arthritis, RheumatoidCurcuminMicroRNAsCell MovementCell ProliferationHumansProtein Inhibitors of Activated STATCurcuminMicroRNAsMIRN126 microRNA, humanPIAS2 protein, humanProtein Inhibitors of Activated STATCurcuminlinc00052protein inhibitor of activated STAT 2rheumatoid arthritis

Identifiers

PMID35473503
PMCPMC9208441
OpenAlexW4224920471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.