Evidence map›Paper›PMID 35473391›Full record

ArticleEpigenomics2022

DNA methylation profile of liver tissue in end-stage cholestatic liver disease.

Angela C Cheung, Brian D Juran, Erik M Schlicht, Bryan M McCauley, Elizabeth J Atkinson, Raymond Moore, Julie K Heimbach, Kymberly D Watt, Tsung-Teh Wu, Nicholas F LaRusso and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Epigenomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Angela C CheungDivision of Gastroenterology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, Canada.
Brian D JuranDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Erik M SchlichtDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Bryan M McCauleyDivision of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN 55905, USA.
Elizabeth J AtkinsonDivision of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN 55905, USA.
Raymond MooreDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Julie K HeimbachDivision of Transplantation Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Kymberly D WattDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Tsung-Teh WuDivision of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Nicholas F LaRussoDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Gregory J GoresDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Zhifu SunDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.
Konstantinos N LazaridisDivision of Gastroenterology & Hepatology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-0437-681X
Mayo Clinic in Arizona · USMayo Clinic · USDepartment of Medical Sciences · BYOttawa Hospital · CA

Funding

PILOT AND FEASIBILTY PROGRAMP30DK084567 · NIDDK · MAYO CLINIC ROCHESTER · PI Samar Ibrahim · 2009 to 2026
$22.2M
Dissecting the pathogenesis and outcomes of PSC using multi-omics by studying the exposome and genomeRC2DK118619 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2018 to 2022
$7.8M
Pathogenesis of Primary Biliary CholangitisR01DK126691 · NIDDK · MAYO CLINIC ROCHESTER · PI LAZARIDIS, KONSTANTINOS N · 2021 to 2024
$2.6M
NIDDK NIH HHS P30 DK084567NIDDK NIH HHS R01 DK126691NIDDK NIH HHS RC2 DK118619
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cholangitis, SclerosingLiver Cirrhosis, BiliaryDNA MethylationEpigenomeHumansLiveralcoholic liver diseasealcoholic steatohepatitiscirrhosisdifferentially methylated regionsDNA methylationepigeneticmethylomeprimary biliary cholangitisprimary biliary cirrhosisprimary sclerosing cholangitis

Identifiers

PMID35473391
PMCPMC9096606
OpenAlexW4225000221

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.