Evidence map›Paper›PMID 35472834›Full record

SynthesisMultiple sclerosis and related disorders2022

Autoimmune encephalitis associated with COVID-19: A systematic review.

Fardin Nabizadeh, Mohammad Balabandian, Fatemeh Sodeifian, Negin Rezaei, Mohammad Reza Rostami, Abdorreza Naser Moghadasi

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Multiple sclerosis and related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025
    Pooled it
  2. Review
  3. Reduced Hospital Incidence of Autoimmune Encephalitis During the COVID-19 Pandemic.Neurology(R) neuroimmunology & neuroinflammation · 2026
    Article
  4. Article
  5. Article
  6. Article
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  12. Article
  13. Features of the clinical course of Autoimmune Encephalitis Associated with various antibodies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Observational
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Controversies in COVID-19: Diagnostic Evaluation and Management in Neuro-COVID.Advances in experimental medicine and biology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Fardin NabizadehNeuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Mohammad BalabandianNeuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Fatemeh SodeifianStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
Negin RezaeiStudent Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Mohammad Reza RostamiNeuroscience Research Group (NRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Abdorreza Naser MoghadasiMultiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: abdorrezamoghadasi@gmail.com.
Universal Scientific Education and Research Network · IRIran University of Medical Sciences · IRShahid Beheshti University · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere are increasing reports of COVID-19 related neurological complications which may be due to direct viral invasion, or immune mediated inflammatory diseases such as autoimmune encephalitis and ADEM (acute demyelinating encephalomyelitis). In this study, a systematic review is presented of the reported cases infected by the COVID-19 who were diagnosed with various forms of autoimmune encephalitis (AE).

methodsThe authors searched three databases including PubMed, Scopus, and Web of science for extracting original articles on coronavirus/ COVID-19 and AE.

resultsEighteen articles were considered in this study, including 15 case reports, and three case series with a total of 81 patients. Among the studies, 19 cases were reported with AE including 7 (37%) cases of limbic encephalitis, 5 (26%) patients with anti-N-methyl-d-aspartate (NMDA) receptor encephalitis, 2 (11%) with AE presenting as new-onset refractory status epilepticus (NORSE), 1 (5%) case of steroid-responsive encephalitis, and 4 (21%) cases with an unknown type of AE.

conclusionOur systematic review revealed evidence on AE development in patients infected with the COVID-19. Clinicians should be aware of the possible diagnosis of AE when considering other neurological differential diagnosis in SARS-CoV-2 infected patients.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisCOVID-19Hashimoto DiseaseEncephalitisHumansSARS-CoV-2Autoimmune encephalitisCOVID-19Systematic review

Identifiers

PMID35472834
PMCPMC8983076
OpenAlexW4225011942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.