Evidence map›Paper›PMID 35472265›Full record

ArticleBiomacromolecules2022

Biocompatibility and Physiological Thiolytic Degradability of Radically Made Thioester-Functional Copolymers: Opportunities for Drug Release.

Nathaniel M Bingham, Qamar Un Nisa, Priyanka Gupta, Neil P Young, Eirini Velliou, Peter J Roth

Open access · hybridAbstract read
In one paragraph

Article in Biomacromolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. On-Demand Chemically Degradable Hydrogels for Biological Applications.Chembiochem : a European journal of chemical biology · 2026
    Review
  4. Article
  5. Article
  6. Topochemical Ring-Opening Polymerization of an Oxathianethione.Journal of the American Chemical Society · 2025
    Article
  7. DegradableACS macro letters · 2024
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nathaniel M BinghamDepartment of Chemistry, School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
Qamar Un NisaDepartment of Chemistry, School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
Priyanka GuptaDepartment of Chemical and Process Engineering, School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
Neil P YoungHolder Building, Department of Materials, University of Oxford, Parks Road, Oxford OX1 3PH, United Kingdom.
Eirini VelliouDepartment of Chemical and Process Engineering, School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.
Peter J RothDepartment of Chemistry, School of Chemistry and Chemical Engineering, University of Surrey, Guildford, Surrey GU2 7XH, United Kingdom.ORCID 0000-0002-8910-9031
University of Surrey · GBUniversity of Oxford · GB

Funding

Medical Research Council MR/V028553/1
6 · The paper itself

Abstract

Being nondegradable, vinyl polymers have limited biomedical applicability. Unfortunately, backbone esters incorporated through conventional radical ring-opening methods do not undergo appreciable abiotic hydrolysis under physiologically relevant conditions. Here, PEG acrylate and di(ethylene glycol) acrylamide-based copolymers containing backbone thioesters were prepared through the radical ring-opening copolymerization of the thionolactone dibenzo[c,e]oxepin-5(7

Indexed as

Polyethylene GlycolsPolymersDrug CarriersDrug LiberationGlutathioneMicellesDrug CarriersGlutathioneMicellesPolyethylene GlycolsPolymers

Identifiers

PMID35472265
PMCPMC9092349
OpenAlexW4224988792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.