Evidence map›Paper›PMID 35471638›Full record

ArticleHuman brain mapping2022

Modulation effect of substantia nigra iron deposition and functional connectivity on putamen glucose metabolism in Parkinson's disease.

Zhenxiang Zang, Tianbin Song, Jiping Li, Shaozhen Yan, Binbin Nie, Shanshan Mei, Jie Ma, Yu Yang, Baoci Shan, Yuqing Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The combination of theScientific reports · 2025
    Article
  6. Correlation of Parkinson's disease severity andQuantitative imaging in medicine and surgery · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Iron Deposition in Parkinson's Disease: A Mini-Review.Cellular and molecular neurobiology · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Zhenxiang ZangDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-6865-054X
Tianbin SongDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiping LiBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Shaozhen YanDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0315-7930
Binbin NieBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, China.
Shanshan MeiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jie MaDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yu YangDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Baoci ShanBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences, China.ORCID 0000-0001-7417-5063
Yuqing ZhangBeijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Jie LuDepartment of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-0425-3921
Capital Medical University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegeneration of the substantia nigra affects putamen activity in Parkinson's disease (PD), yet in vivo evidence of how the substantia nigra modulates putamen glucose metabolism in humans is missing. We aimed to investigate how substantia nigra modulates the putamen glucose metabolism using a cross-sectional design. Resting-state fMRI, susceptibility-weighted imaging, and [

Indexed as

Parkinson DiseasePutamenCross-Sectional StudiesFluorodeoxyglucose F18GlucoseHumansIronMagnetic Resonance ImagingSubstantia NigraFluorodeoxyglucose F18GlucoseIronnigral iron depositionnigrostriatal functional connectivityParkinson's diseaseputamen metabolism distribution

Identifiers

PMID35471638
PMCPMC9294292
OpenAlexW4224920927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.