ArticleAdvances in experimental medicine and biology2022
Reconstruction of the Hippocampus.
Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Maternal Acrylamide Exposure Modulates Parvalbumin-Positive Interneurons in the Subiculum and Hippocampus of Rat Offspring.Biomolecules · 2026Article
- Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.PLoS biology · 2024Article
- Identification of a Hippocampus-to-Zona Incerta Projection involved in Motor Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A realistic computational model for the formation of a Place Cell.Scientific reports · 2023Article
- Online interoperable resources for building hippocampal neuron models via the Hippocampus Hub.Frontiers in neuroinformatics · 2023Article
- Quantitative analysis of the optogenetic excitability of CA1 neurons.Frontiers in computational neuroscience · 2023Article
- A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits.Scientific reports · 2022Article
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
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Authors and funding
4 authors.
Funding
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Abstract
The hippocampus is a widely studied brain region thought to play an important role in higher cognitive functions such as learning, memory, and navigation. The amount of data on this region increases every day and delineates a complex and fragmented picture, but an integrated understanding of hippocampal function remains elusive. Computational methods can help to move the research forward, and reconstructing a full-scale model of the hippocampus is a challenging yet feasible task that the research community should undertake.In this chapter, we present strategies for reconstructing a large-scale model of the hippocampus. Based on a previously published approach to reconstruct and simulate brain tissue, which is also explained in Chap. 10 , we discuss the characteristics of the hippocampus in the light of its special anatomical and physiological features, data availability, and existing large-scale hippocampus models. A large-scale model of the hippocampus is a compound model of several building blocks: ion channels, morphologies, single cell models, connections, synapses. We discuss each of those building blocks separately and discuss how to merge them back and simulate the resulting network model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.