ArticleJournal of applied genetics2022
No evidence that long runs of homozygosity tend to harbor risk variants for polygenic obesity in Labrador retriever dogs.
Article in Journal of applied genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Circulating pTau181 and Genomic Background in Dogs: A Pilot Study on Neurobiological Aging.Veterinary medicine international · 2026Article
- Biliverdinuria Caused by ExonicGenes · 2024Article
- A Study of 41 Canine Orthologues of Human Genes Involved in Monogenic Obesity Reveals Marker in theVeterinary sciences · 2023Article
- Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.Frontiers in genetics · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Canine polygenic obesity can be influenced by relatively recent mutations with large effects. We determined whether, as with monogenic diseases, long autozygous tracts may be disproportionately likely to harbor detrimental variants for additive polygenic obesity in Labrador retriever dogs. Both our detection of runs of homozygosity (ROH) and our preliminary association study were based on whole-genome sequencing of 28 obese and 22 healthy dogs. We detected and analyzed the distribution of 19,655 ROH. We observed 237 and 98 ROH-harboring genotypes associated with obesity and increased body mass, respectively. We found no evidence that long ROH tend to harbor genotypes linked to obesity or increased body weight, and we concluded that data on ROH overlapping GWAS signals for canine obesity are unlikely to help prioritize candidate genes for validation studies.
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